Natural Colonization with Helicobacter species and the Development of Inflammatory Bowel Disease in Interleukin‐10‐deficient Mice

Natural Colonization with Helicobacter species and the Development of Inflammatory Bowel Disease in Interleukin‐10‐deficient Mice
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螺杆菌自然定植和白细胞介素 10 缺陷小鼠炎症性肠病的发生

DOI:
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发表时间:
2005
期刊:
影响因子:
4.4
通讯作者:
Hazel M. Mitchell
Hazel M. Mitchell
中科院分区:
医学2区
文献类型:
--
作者:
Li Zhang;S. Danon;M. Grehan;Vivian Chan;Adrian K. C. Lee;Hazel M. Mitchell

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背景。在无特定病原体(SPF)条件下维持的白细胞介素- 10缺陷(IL - 10−/ -)小鼠在实验中感染幽门螺杆菌后发生伤寒结肠炎。然而,关于自然定植IL - 10−/ -小鼠的幽门螺杆菌物种在伤寒结肠炎发展中的作用的信息有限。本研究的目的是在SPF IL‐10−/ -小鼠中研究自然定植特异性幽门螺杆菌物种与伤寒结肠炎发展之间的关系。
Background.  The interleukin‐10‐deficient (IL‐10−/–) mice maintained in specific‐pathogen‐free (SPF) conditions develop typhlocolitis when experimentally infected with Helicobacter species. However, there is limited information regarding the role of Helicobacter species that naturally colonize IL‐10−/– mice in typhlocolitis development. The aim of this study was to examine in SPF IL‐10−/– mice the association between natural colonization specific Helicobacter species and typhlocolitis development.
DOI: 10.1099/00207713-47-3-627
发表时间: 1997-07
期刊: International journal of systematic bacteriology
影响因子: --
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DOI: --
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影响因子: --
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发表时间: 2001-09-01
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