Changing hepatocellular carcinoma incidence and liver cancer mortality rates in the United States.
Changing hepatocellular carcinoma incidence and liver cancer mortality rates in the United States.
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DOI：
10.1038/ajg.2014.11
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发表时间：
2014-04
影响因子：
9.8
通讯作者：
McGlynn, Katherine A.
中科院分区：
文献类型：
--
作者：
Altekruse, Sean F.;Henley, S. Jane;Cucinelli, James E.;McGlynn, Katherine A.
按地理位置、年龄、人种/种族和性别描述监测、流行病学和最终结果（SEER）肝细胞癌（HCC）发病率趋势和美国肝癌死亡率趋势。分析了SEER 18登记处的HCC发病率数据和国家卫生统计中心的肝癌死亡率数据。按人口统计学亚组计算发生率和关节点趋势。绘制了州一级肝癌死亡率和趋势图。SEER登记研究中的HCC发病率在2007-2010年期间没有显著增加，但美国肝癌死亡率确实增加。在所有种族/族裔群体（包括亚洲人/太平洋岛民）中，50岁以上黑人、西班牙裔和白色男性的HCC发病率和肝癌死亡率增加，35-49岁男性的HCC发病率和肝癌死亡率下降。妇女中发病率和死亡率显著增加的仅限于50岁以上的黑人、西班牙裔和白人。2000-2010年期间，亚洲/太平洋岛民肝癌死亡率下降，50-64岁妇女和35-49岁男子的死亡率下降，其他群体的死亡率保持稳定。2006-2010年期间，在50-64岁的人群中，黑人和西班牙裔的发病率和死亡率高于亚裔/太平洋岛民。肝癌死亡率最高的是路易斯安那州、密西西比州、德克萨斯州和华盛顿特区。亚洲/太平洋岛屿居民，35-49岁男性的肝癌发病率和肝癌死亡率下降，以及整体肝癌发病率的非显着增加表明，流行病的高峰期可能接近或已经过去。发现死亡率的地理差异可以为控制工作提供信息。
To describe Surveillance, Epidemiology and End Results (SEER) hepatocellular carcinoma (HCC) incidence trends and United States liver cancer mortality trends by geography, age, race/ethnicity and gender. HCC incidence data from SEER 18 registries and liver cancer mortality data from the National Center for Health Statistics were analyzed. Rates and joinpoint trends were calculated by demographic subgroup. State-level liver cancer mortality rates and trends were mapped. HCC incidence rates in SEER registries did not significantly increase during 2007–2010, however U.S. liver cancer mortality rates did increase. HCC incidence and liver cancer mortality rates increased among black, Hispanic and white men aged 50+ years and decreased among 35–49 year old men in all racial/ethnic groups including Asians/Pacific Islanders. Significantly increasing incidence and mortality rates among women were restricted to blacks, Hispanics and whites aged 50+ years. Asian/Pacific Islander liver cancer mortality rates decreased during 2000–2010 with decreasing rates among women aged 50–64 years and men 35–49 years and stable rates in other groups. During 2006–2010 among person 50–64 years of age, blacks and Hispanics had higher incidence and mortality rates than Asians/Pacific Islanders. Liver cancer mortality rates were highest in Louisiana, Mississippi, Texas and Washington, DC. Decreasing HCC incidence and liver cancer mortality rates among Asian/Pacific Islanders, men aged 35–49 years, and the non-significant increase in overall HCC incidence rates suggest that the peak of the epidemic may be near or have passed. Findings of geographic variation in mortality rates can inform control efforts.
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影响因子：
29.4
作者：
El-Serag HB
通讯作者：
El-Serag HB
影响因子：
--
作者：
Kew, M. C.
通讯作者：
Kew, M. C.
影响因子：
45.3
作者：
Altekruse, Sean F.;McGlynn, Katherine A.;Reichman, Marsha E.
通讯作者：
Reichman, Marsha E.
影响因子：
3
作者：
Mizokami, M;Tanaka, Y
通讯作者：
Tanaka, Y
影响因子：
158.5
作者：
Calle, EE;Rodriguez, C;Thun, MJ
通讯作者：
Thun, MJ