The bacterial pathogen Listeria monocytogenes and the interferon family: type I, type II and type III interferons.

The bacterial pathogen Listeria monocytogenes and the interferon family: type I, type II and type III interferons.
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DOI:
10.3389/fcimb.2014.00050
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发表时间:
2014
影响因子:
5.7
通讯作者:
Cossart P
Cossart P
中科院分区:
医学2区
文献类型:
--
作者:
Dussurget O;Bierne H;Cossart P

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干扰素(IFN)是调节对感染的先天性和适应性免疫应答的细胞因子家族的分泌蛋白。虽然IFN在抗病毒反应中的重要性早已被认识到,但它们在细菌感染中的作用更为复杂,目前是研究的主要焦点。这篇综述总结了我们目前的知识,这些细胞因子在宿主防御细菌病原体单核细胞增生李斯特菌的作用,并强调了最近发现的分子机制,这种细胞内的细菌,颠覆IFN的反应。
Interferons (IFNs) are secreted proteins of the cytokine family that regulate innate and adaptive immune responses to infection. Although the importance of IFNs in the antiviral response has long been appreciated, their role in bacterial infections is more complex and is currently a major focus of investigation. This review summarizes our current knowledge of the role of these cytokines in host defense against the bacterial pathogen Listeria monocytogenes and highlights recent discoveries on the molecular mechanisms evolved by this intracellular bacterium to subvert IFN responses.
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