Confounding roles for type I interferons during bacterial and viral pathogenesis.
Confounding roles for type I interferons during bacterial and viral pathogenesis.
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DOI：
10.1093/intimm/dxt050
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发表时间：
2013-12
影响因子：
4.4
通讯作者：
Carrero JA
中科院分区：
文献类型：
--
作者：
Carrero JA
I型干扰素在病毒和细菌感染中可以是保护性的或有害的。虽然I型干扰素（IFN-I）最初被定义为有效的抗病毒剂，但它们也可导致宿主对某些细菌和病毒感染的抵抗力下降。IFN-I的许多抗病毒功能包括直接抑制病毒复制和激活针对病毒的免疫应答。除抗病毒作用外，IFN-I还部分通过促进TNF-α和一氧化氮的诱导而保护免受几种细胞外细菌感染。相反，在淋巴细胞性脉络丛脑膜炎病毒（LCMV）慢性感染和细胞内细菌急性感染期间，IFN-1对宿主抗性有负面影响。在LCMV的情况下，慢性IFN-I信号传导诱导适应性免疫系统抑制。阻断IFN-I信号传导消除了抑制作用，并允许CD 4 T细胞和IFN-γ介导的感染消退。在急性细胞内细菌感染期间，IFN-I通过至少两种确定的机制抑制先天性免疫。在弗朗西斯菌感染期间，IFN-I阻止γδ T细胞上的IL-17上调和中性粒细胞募集。李斯特菌感染后，IFN-I促进巨噬细胞和淋巴细胞的细胞死亡，这导致先天免疫抑制。这些不同的发现IFN-I对病原体控制的作用强调了干扰素系统的复杂性，并迫使更多的机制评估其在发病机制中的作用。这篇综述评估了IFN-I在感染过程中的工作进行了IFN-I受体缺陷小鼠的重点。
Type I interferons can be protective or deleterious in viral and bacterial infections. Although type I interferons (IFN-I) were initially defined as potent antiviral agents, they can also cause decreased host resistance to some bacterial and viral infections. The many antiviral functions of the IFN-I include direct suppression of viral replication and activation of the immune response against viruses. In addition to their antiviral effects, IFN-I are also protective against several extracellular bacterial infections, in part, by promoting the induction of TNF-α and nitric oxide. In contrast, there is a negative effect of IFN-I on host resistance during chronic infection with lymphocytic choriomeningitis virus (LCMV) and acute infections with intracellular bacteria. In the case of LCMV, chronic IFN-I signaling induces adaptive immune system suppression. Blockade of IFN-I signaling removes the suppression and allows CD4 T-cell- and IFN-γ-mediated resolution of the infection. During acute intracellular bacterial infection, IFN-I suppress innate immunity by at least two defined mechanisms. During Francisella infection, IFN-I prevent IL-17 upregulation on γδ T cells and neutrophil recruitment. Following Listeria infection, IFN-I promote the cell death of macrophages and lymphocytes, which leads to innate immune suppression. These divergent findings for the role of IFN-I on pathogen control emphasize the complexity of the interferons system and force more mechanistic evaluation of its role in pathogenesis. This review evaluates IFN-I during infection with an emphasis on work carried out IFN-I-receptor-deficient mice.
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DOI：
10.4049/jimmunol.1200255
发表时间：
2012-06-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Desvignes L;Wolf AJ;Ernst JD
通讯作者：
Ernst JD
影响因子：
15.9
作者：
Antonelli, Lis R. V.;Rothfuchs, Antonio Gigliotti;Sher, Alan
通讯作者：
Sher, Alan
影响因子：
32.4
作者：
Jego, G;Palucka, AK;Banchereau, J
通讯作者：
Banchereau, J
影响因子：
15.3
作者：
Carrero, JA;Calderon, B;Unanue, ER
通讯作者：
Unanue, ER
影响因子：
64.8
作者：
Barton, Erik S.;White, Douglas W.;Virgin, Herbert W.
通讯作者：
Virgin, Herbert W.