Measurement of admixture proportions and description of admixture structure in different U.S. populations.
Measurement of admixture proportions and description of admixture structure in different U.S. populations.
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DOI：
10.1002/humu.21045
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发表时间：
2009-09
期刊：
影响因子：
3.9
通讯作者：
Gelernter, Joel
中科院分区：
文献类型：
--
作者：
Halder, Indrani;Yang, Bao-Zhu;Kranzler, Henry R.;Stein, Murray B.;Shriver, Mark D.;Gelernter, Joel
个体混合比例的变化导致群体内的异质性。虽然已经开发了新的方法和标记面板来量化单个混合物，但描述单个混合物分布的经验数据有限。我们调查了四个美国人群[欧洲裔美国人（EA），非洲裔美国人（AA）和来自康涅狄格州（EC）和加州（WC）的西班牙裔]中个体混合物的变化，假设欧洲人，非洲人和土著美国人之间存在三种混合。混合物估计推断使用一组36个微卫星和1个SNP，这有显着的等位基因频率差异之间的祖先种群，并通过使用最大似然（ML）为基础的方法和贝叶斯方法中实现的程序结构。模拟研究表明，用该标记面板获得的估计值在预期值的96%以内。EA有最低的非欧洲混合物与这两种方法，但表现出更大的同质性与结构比ML。所有其他样品显示出两种方法混合物估计值的高度变异，高度一致，并显示出混合物分层的证据。使用这两种方法，AA受试者平均有16%的欧洲人和<10%的美洲土著人。EC西班牙裔有较高的平均非洲混合物和WC西班牙裔较高的平均土著美国人混合物，可能反映了他们不同的大陆起源。
Variation in individual admixture proportions leads to heterogeneity within populations. Though novel methods and marker panels have been developed to quantify individual admixture, empirical data describing individual admixture distributions are limited. We investigated variation in individual admixture in four US populations [European American (EA), African American (AA) and Hispanics from Connecticut (EC) and California (WC)] assuming three-way intermixture among Europeans, Africans and Indigenous Americans. Admixture estimates were inferred using a panel of 36 microsatellites and 1 SNP, which have significant allele frequency differences between ancestral populations, and by using both a maximum likelihood (ML) based method and a Bayesian method implemented in the program STRUCTURE. Simulation studies showed that estimates obtained with this marker panel are within 96% of expected values. EAs had the lowest non-European admixture with both methods, but showed greater homogeneity with STRUCTURE than with ML. All other samples showed a high degree of variation in admixture estimates with both methods, were highly concordant and showed evidence of admixture stratification. With both methods, AA subjects had 16% European and <10% Indigenous American admixture on average. EC Hispanics had higher mean African admixture and the WC Hispanics higher mean Indigenous American admixture, possibly reflecting their different continental origins.
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影响因子：
1.8
作者：
Heiman, GA;Hodge, SE;Greenberg, DA
通讯作者：
Greenberg, DA
影响因子：
9.8
作者：
Bauchet, Marc;McEvoy, Brian;Shriver, Mark D.
通讯作者：
Shriver, Mark D.
影响因子：
7
作者：
Kayser, M;Brauer, S;Stoneking, M
通讯作者：
Stoneking, M
影响因子：
2.8
作者：
LONG, JC;WILLIAMS, RC;IWANIEC, U
通讯作者：
IWANIEC, U
影响因子：
5.3
作者：
Bonilla, C;Shriver, MD;Fernández, JR
通讯作者：
Fernández, JR