Trends of incidence and survival in patients with gastrointestinal mucinous adenocarcinoma.
Trends of incidence and survival in patients with gastrointestinal mucinous adenocarcinoma.
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胃肠道粘液腺癌患者的发病率和生存率趋势
DOI：
10.3892/ol.2018.9394
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发表时间：
2018-11
期刊：
影响因子：
2.9
通讯作者：
Yi C
中科院分区：
文献类型：
--
作者：
Zong Z;Luo Y;Ying H;Wang A;Li H;Yi C
胃肠道粘液腺癌的流行病学和临床结果还没有很好的说明。本研究旨在探讨影响胃肠道MA患者生存率的流行病学和预后因素。使用2000年至2014年监测、流行病学和最终结果（SEER）项目的全国代表性数据，进行了一项回顾性和基于人群的研究，以确定胃肠道粘液性MA的年年龄校正发病率、总生存期（OS）和生存趋势。Kaplan-Meier曲线和考克斯比例回归模型用于评估该疾病的预后因素。在51632例病例中，女性占50.5%（26058例）。从2000年到2014年，MA的年发病率稳步下降。除阑尾外，所有分期、年级和部位均出现这种趋势。在SEER 18登记组（2000-2014）中，结肠的最高发病率为每10万人3.333例。根据多变量分析，不同原发部位、分期、分级和临床诊断年龄以及诊断时间段之间的中位OS差异显著。胃肠道MA的5年OS在2000年至2014年期间逐渐改善。在相同的时间间隔内，远端胃肠道MA亚组的生存率改善更为明显。除阑尾外，消化道沿着的所有部位均显示MA发生率降低。观察到大多数胃肠道的生存率提高，尤其是晚期疾病患者。与结直肠MA相比，上消化道MA发生率较低，但生存率较差。临床医生在制定胃肠道MA的治疗指南和治疗决策时应考虑原发肿瘤部位。
The epidemiology and clinical outcome of gastrointestinal mucinous adenocarcinoma (MA) are not well illustrated. The present study aimed to explore the evolving epidemiology and prognostic factors that affect the survival of patients with MA in the gastrointestinal tract. A retrospective and population-based study was conducted to determine the annual age-adjusted incidence, overall survival (OS) and survival trend of gastrointestinal mucinous MA using nationally representative data from the Surveillance, Epidemiology, and End Results (SEER) program between 2000 and 2014. A Kaplan-Meier curve and a Cox proportional regression model were used to evaluate prognostic factors for this disease. Of the 51632 cases, females accounted for 50.5% (26058). The annual incidence of MA steadily decreased from 2000 to 2014. This trend occurred across all stages, grades and sites, apart from the appendix. In the SEER 18 registry grouping (2000–2014), the highest incidence was 3.333 per 100,000 persons for the colon. The median OS varied significantly between different primary sites, stages, grades, and age of clinical diagnosis, and the time period of diagnosis, according to a multivariable analysis. The five-year OS of gastrointestinal MA improved gradually between 2000 and 2014. The improvement in survival over the same interval was more pronounced in the subgroup of distant gastrointestinal MA. All sites along the alimentary tract, with the exception of the appendix, showed a decrease in the incidence of MA. Improved survival rates were observed for most of the gastrointestinal tract, especially for patients with advanced stage disease. MA in the upper gastrointestinal tract was less frequent but had poorer survival than colorectal MA. Clinicians should consider the primary tumour site when making therapeutic guidelines and treatment decisions for gastrointestinal MA.
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影响因子：
3.2
作者：
Numata M;Shiozawa M;Watanabe T;Tamagawa H;Yamamoto N;Morinaga S;Watanabe K;Godai T;Oshima T;Fujii S;Kunisaki C;Rino Y;Masuda M;Akaike M
通讯作者：
Akaike M
影响因子：
3.7
作者：
Hyngstrom JR;Hu CY;Xing Y;You YN;Feig BW;Skibber JM;Rodriguez-Bigas MA;Cormier JN;Chang GJ
通讯作者：
Chang GJ
影响因子：
9
作者：
Nitsche U;Zimmermann A;Späth C;Müller T;Maak M;Schuster T;Slotta-Huspenina J;Käser SA;Michalski CW;Janssen KP;Friess H;Rosenberg R;Bader FG
通讯作者：
Bader FG
影响因子：
4.5
作者：
PIHL, E;NAIRN, RC;ROLLO, AJ
通讯作者：
ROLLO, AJ
影响因子：
2.7
作者：
Hsu, Jun-Te;Chen, Han-Ming;Chen, Miin-Fu
通讯作者：
Chen, Miin-Fu