Quantitative analyses of schizophrenia-associated metabolites in serum: serum D-lactate levels are negatively correlated with gamma-glutamylcysteine in medicated schizophrenia patients.
Quantitative analyses of schizophrenia-associated metabolites in serum: serum D-lactate levels are negatively correlated with gamma-glutamylcysteine in medicated schizophrenia patients.
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DOI：
10.1371/journal.pone.0101652
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Yoshio T
中科院分区：
文献类型：
--
作者：
Fukushima T;Iizuka H;Yokota A;Suzuki T;Ohno C;Kono Y;Nishikiori M;Seki A;Ichiba H;Watanabe Y;Hongo S;Utsunomiya M;Nakatani M;Sadamoto K;Yoshio T
精神分裂症患者血清中几种代谢物水平发生明显变化。在这项研究中，我们对精神分裂症患者(n = 25)的34种候选代谢物进行了有针对性的分析，并将它们与年龄和性别匹配的健康受试者(n = 27)进行了比较。正交偏最小二乘判别分析表明，基于这些代谢物实现了对照组和患者之间的完全分离。结果发现，精神分裂症患者血清γ-谷氨酰半胱氨酸(γ-GluCys)、亚油酸、花生四烯酸、D-丝氨酸、3-羟丁酸、谷胱甘肽、5-羟色胺、苏氨酸和酪氨酸水平显著低于对照组，而D-乳酸、色氨酸、犬尿氨酸和谷氨酸水平显著高于对照组。用受试者工作特征曲线分析，谷胱甘肽前体γ-GluCys和丙二醛的终末代谢物D-乳酸的敏感性、特异性和曲线下面积分别为88.00%、81.48%和0.8874和88.00%、77.78%和0.8415。此外，患者的血清D-乳酸水平与γ-GluCys水平呈负相关，而在对照组中则不相关。提示氧化应激损伤可能参与了精神分裂症的发病机制。
The serum levels of several metabolites are significantly altered in schizophrenia patients. In this study, we performed a targeted analysis of 34 candidate metabolites in schizophrenia patients (n = 25) and compared them with those in age- and gender-matched healthy subjects (n = 27). Orthogonal partial least square-discriminant analysis revealed that complete separation between controls and patients was achieved based on these metabolites. We found that the levels of γ-glutamylcysteine (γ-GluCys), linoleic acid, arachidonic acid, D-serine, 3-hydroxybutyrate, glutathione (GSH), 5-hydroxytryptamine, threonine, and tyrosine were significantly lower, while D-lactate, tryptophan, kynurenine, and glutamate levels were significantly higher in schizophrenia patients compared to controls. Using receiver operating characteristics (ROC) curve analysis, the sensitivity, specificity, and the area under curve of γ-GluCys, a precursor of GSH, and D-lactate, a terminal metabolite of methylglyoxal, were 88.00%, 81.48%, and 0.8874, and 88.00%, 77.78%, and 0.8415, respectively. In addition, serum levels of D-lactate were negatively correlated with γ-GluCys levels in patients, but not in controls. The present results suggest that oxidative stress-induced damage may be involved in the pathogenesis of schizophrenia.
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影响因子：
2.5
作者：
Erhardt, S;Blennow, K;Engberg, G
通讯作者：
Engberg, G
影响因子：
1.8
作者：
Fukushima, T;Kawai, J;Toyo'oka, T
通讯作者：
Toyo'oka, T
影响因子：
1.8
作者：
Hubbard, K. Elaine;Wells, Amy;Stewart, Clinton F.
通讯作者：
Stewart, Clinton F.
DOI：
10.1002/ajmg.b.31004
发表时间：
2010-03-01
影响因子：
2.8
作者：
Iwayama, Yoshimi;Hattori, Eiji;Yoshikawa, Takeo
通讯作者：
Yoshikawa, Takeo
影响因子：
5
作者：
Fukushima, Takeshi;Mitsuhashi, Shogo;Toyo'oka, Toshimasa
通讯作者：
Toyo'oka, Toshimasa