Expression of the Wnt signaling system in central nervous system axon guidance and regeneration.
Expression of the Wnt signaling system in central nervous system axon guidance and regeneration.
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DOI：
10.3389/fnmol.2012.00005
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发表时间：
2012
影响因子：
4.8
通讯作者：
Zou Y
中科院分区：
文献类型：
--
作者：
Hollis ER 2nd;Zou Y
在脊椎动物和无脊椎动物神经系统的整个发育过程中，Wnt信号对于轴突布线至关重要。在啮齿类动物中，Wnt以跨越脊髓中的整个前后（A-P）轴和上级丘中的内侧-外侧轴的梯度表达。在脑干中，Wnt沿着A-P轴以更复杂的梯度表达。这些梯度为轴突寻路提供方向信息，为地形图提供位置信息，并通过生长锥中的细胞极性信号通路检测。Wnt的梯度表达和Wnt信号系统的协调表达受目前未知的机制调节。成年脊髓损伤导致损伤部位周围多种细胞类型中Wnt的重新诱导及其损伤轴突中的信号系统。再诱导的Wnt在病变部位周围形成梯度，病变部位是峰值。再诱导的Wnt可能通过受体Ryk（相关受体酪氨酸激酶）负责已知的下行运动轴突的收缩。Wnt信号转导是CNS修复的一个有吸引力的新治疗靶点。调节再诱导的机制尚不清楚，但将为治疗设计提供信息。
Wnt signaling is essential for axon wiring throughout the development of the nervous system in vertebrates and invertebrates. In rodents, Wnts are expressed in gradients that span the entire anterior–posterior (A–P) axis in the spinal cord and the medial–lateral axis in the superior colliculus. In the brainstem, Wnts are expressed in more complex gradients along the A–P axis. These gradients provide directional information for axon pathfinding and positional information for topographic mapping and are detected by cell polarity signaling pathways in the growth cone. The gradient expression of Wnts and the coordinated expression of Wnt signaling systems are regulated by mechanisms which are currently unknown. Injury to the adult spinal cord results in the re-induction of Wnts in multiple cell types around the lesion site and their signaling system in injured axons. The re-induced Wnts form gradients around the lesion site, with the lesion site being the peak. The re-inducedWnts may be responsible for the well-known retraction of descending motor axons through the receptor Ryk (related receptor tyrosine kinases). Wnt signaling is an appealing new therapeutic target for CNS repair. The mechanisms regulating the re-induction are unknown but will be informative for therapeutic design.
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影响因子：
64.8
作者：
Bonkowsky, JL;Yoshikawa, S;Thomas, JB
通讯作者：
Thomas, JB
影响因子：
25
作者：
Liu, YB;Shi, J;Zou, YM
通讯作者：
Zou, YM
DOI：
10.1523/jneurosci.4508-10.2010
发表时间：
2010-11-24
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fenstermaker AG;Prasad AA;Bechara A;Adolfs Y;Tissir F;Goffinet A;Zou Y;Pasterkamp RJ
通讯作者：
Pasterkamp RJ
影响因子：
4.7
作者：
Matsuura, Iichiro;Taniguchi, Junko;Yamashita, Toshihide
通讯作者：
Yamashita, Toshihide
影响因子：
4.2
作者：
Miyashita, Tomohiro;Koda, Masao;Yamashita, Toshihide
通讯作者：
Yamashita, Toshihide