Sex differences in cardiometabolic traits at four life stages: cohort study with repeated metabolomics
Sex differences in cardiometabolic traits at four life stages: cohort study with repeated metabolomics
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四个生命阶段心脏代谢特征的性别差异：重复代谢组学的队列研究
DOI：
10.1101/2020.01.15.19015206
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Bell J
中科院分区：
文献类型：
--
作者：
Bell J
研究背景男性冠心病（CHD）的发病率高于女性，但对造成这种差异的循环特征知之甚少。我们研究了详细的心脏代谢特征测量在四个生命阶段的性别差异，跨越童年到中年adulthy.Methods和ResultsData从雅芳纵向研究的父母和儿童队列研究。对1991-92年出生的后代（第1代（G1））和其父母（第0代（G 0））重复测量了229个从靶向代谢组学（核磁共振光谱）定量的性状，包括脂蛋白亚类特异性胆固醇和甘油三酯、氨基酸、葡萄糖和炎性糖蛋白乙酰基。在G1中，在儿童期（平均年龄8岁）测量一次，在青春期（16岁和18岁）测量两次，在成年早期（25岁）测量一次，在G 0中，在成年中期（50岁）测量一次。线性回归模型被用来检查男性与女性相比，在每一个场合的标准化性状的差异（系列横截面协会）。7，727名G1（49%男性）和6，500名G 0（29%男性）参与了分析。在8岁时，男性的极低密度脂蛋白（VLDL）中的总脂质低于女性;在16岁时，男性的水平高于女性，在18岁和50岁时（G 0），中等或更大的亚类仍然更高。VLDL中甘油三酯的较大性别差异在年龄较大时最为明显-例如，男性水平在18岁时高0.19标准差（SD）单位（95% CI=0.12，0.26），在25岁时高0.50 SD（95% CI=0.42，0.57），在50岁时高0.62 SD（95% CI=0.55，0.68）。极低密度脂蛋白和低密度脂蛋白（LDL）中的胆固醇在男性中普遍较低，不同年龄段的性别差异不一致。雄性的载脂蛋白-B通常低于雌性。支链氨基酸在8岁后的男性中始终较高，在所有年龄的所有性状中，在50岁时观察到亮氨酸的最大性别差异（1.53 SD，95% CI=1.47，男性比女性高1.58）。男性一贯较低的糖蛋白acetyls across age.ConclusionsOur结果表明，男性开始有较高的VLDL甘油三酯在青春期，这种性别差异是较大的年龄。其他CHD相关特征的性别差异，包括LDL胆固醇、载脂蛋白B和炎性糖蛋白，随着年龄的增长表现出相反的模式，女性中的水平较高。因此，较高的甘油三酯含量可能是一个关键因素，支持较高的年龄调整率的冠心病男性;因果关系分析，这和其他特征需要了解他们是否差异影响冠心病的风险男性和女性。
BackgroundMales experience higher rates of coronary heart disease (CHD) than females, but the circulating traits underpinning this difference are poorly understood. We examined sex differences in detailed cardiometabolic traits measured at four life stages, spanning childhood to middle adulthood.Methods and ResultsData were from the Avon Longitudinal Study of Parents and Children cohort study. 229 traits quantified from targeted metabolomics (nuclear magnetic resonance spectroscopy) including lipoprotein subclass-specific cholesterol and triglycerides, amino acids, glucose, and inflammatory glycoprotein acetyls were measured repeatedly in offspring (Generation 1 (G1)) born in 1991-92 and once in their parents (Generation 0 (G0)). Measurements in G1 were once in childhood (mean age 8y), twice in adolescence (16y and 18y) and once in early adulthood (25y), and in G0 once in middle adulthood (50y). Linear regression models were used to examine differences in standardized traits for males compared with females on each occasion (serial cross-sectional associations). 7,727 G1s (49% male) and 6,500 G0s (29% male) contributed to analyses. At age 8y, total lipids in very-low-density lipoproteins (VLDL) were lower in males than females; levels were higher in males than females at age 16y and were higher still by age 18y and age 50y (in G0) for medium-or-larger subclasses. Larger sex differences at older ages were most pronounced for triglycerides in VLDL – e.g. male levels were 0.19 standard deviation (SD) units (95% CI=0.12, 0.26) higher at age 18y, 0.50 SD (95% CI=0.42, 0.57) higher at age 25y, and 0.62 SD (95% CI=0.55, 0.68) higher at age 50y. Cholesterol in VLDL and low-density lipoproteins (LDL) was generally lower in males, with inconsistent sex differences across ages. Apolipoprotein-B was generally lower in males than females. Branched chain amino acids were consistently higher in males after age 8y with the largest sex difference of all traits at all ages seen for leucine at age 50y (1.53 SD, 95% CI=1.47, 1.58 higher in males compared with females). Males had consistently lower glycoprotein acetyls across ages.ConclusionsOur results suggest that males begin to have higher VLDL triglycerides in adolescence, and that this sex difference is larger at older ages. Sex differences in other CHD-related traits, including LDL cholesterol, apolipoprotein-B, and inflammatory glycoproteins, show the opposite pattern with age, with higher levels among females. Higher triglyceride content may therefore be a key factor underpinning the higher age-adjusted rate of CHD among males; causal analyses of this and other traits are needed to understand whether they differentially affect CHD risk among males and females.
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DOI：
10.1056/nejmoa1406656
发表时间：
2015-04-02
期刊：
The New England journal of medicine
影响因子：
--
作者：
Roth GA;Forouzanfar MH;Moran AE;Barber R;Nguyen G;Feigin VL;Naghavi M;Mensah GA;Murray CJ
通讯作者：
Murray CJ
影响因子：
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作者：
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通讯作者：
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DOI：
10.1016/s0140-6736(17)32152-9
发表时间：
2017-09-16
期刊：
Lancet (London, England)
影响因子：
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作者：
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通讯作者：
GBD 2016 Causes of Death Collaborators
影响因子：
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作者：
Link JC;Reue K
通讯作者：
Reue K
影响因子：
24
作者：
Sidney, Stephen;Quesenberry, Charles P., Jr.;Rana, Jamal S.
通讯作者：
Rana, Jamal S.