Genetic Basis for Sex Differences in Obesity and Lipid Metabolism.
Genetic Basis for Sex Differences in Obesity and Lipid Metabolism.
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DOI：
10.1146/annurev-nutr-071816-064827
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发表时间：
2017-08-21
影响因子：
8.9
通讯作者：
Reue K
中科院分区：
文献类型：
--
作者：
Link JC;Reue K
男性和女性在肥胖、心血管疾病和糖尿病方面表现出显著差异。为了更好地为两性提供诊断和治疗，重要的是要确定所观察到的性别差异的基础因素。传统上，性别差异被归因于男性和女性性腺分泌物（通常称为“性激素”）的不同作用，这确实对新陈代谢和相关疾病的许多方面产生了重大影响。作为性别差异的贡献者，男性和女性之间的基本遗传差异不太受重视，这最终取决于XX或XY性染色体补体的存在。在这里，我们审查的机制，性腺激素和性染色体互补各自有助于脂质代谢和相关疾病，以及目前的方法，用于研究它们。我们特别关注遗传方法，包括人类和小鼠的全基因组关联研究，“组学”和“系统遗传学”方法，以及独特的实验小鼠模型，可以区分性腺和性染色体的影响。
Men and women exhibit significant differences in obesity, cardiovascular disease and diabetes. To provide better diagnosis and treatment for both sexes, it is important to identify factors that underlie the observed sex differences. Traditionally, sex differences have been attributed to the differential effects of male and female gonadal secretions (commonly referred to as “sex hormones”), which do substantially influence many aspects of metabolism and related diseases. Less appreciated as a contributor to sex differences are the fundamental genetic differences between males and females, which are ultimately determined by the presence of an XX or XY sex chromosome complement. Here we review the mechanisms by which gonadal hormones and sex chromosome complement each contribute to lipid metabolism and associated diseases, and the current approaches that are used to study them. We focus particularly on genetic approaches including genome-wide association studies in humans and mice, “–omics” and “systems genetics” approaches, and unique experimental mouse models that allow distinction between gonadal and sex chromosome effects.
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影响因子：
2.5
作者：
Arnold, Arthur P.;Chen, Xuqi;Link, Jenny C.;Itoh, Yuichiro;Reue, Karen
通讯作者：
Reue, Karen
DOI：
10.1016/j.jsbmb.2007.09.001
发表时间：
2008-02-01
影响因子：
4.1
作者：
Blouin, Karine;Boivin, Ariane;Tchernof, Andre
通讯作者：
Tchernof, Andre
影响因子：
7.4
作者：
Arnold, Arthur P.;Chen, Xuqi
通讯作者：
Chen, Xuqi
影响因子：
13.5
作者：
Browning, JD;Szczepaniak, LS;Hobbs, HH
通讯作者：
Hobbs, HH
DOI：
10.1126/science.1262110
发表时间：
2015-05-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
GTEx Consortium
通讯作者：
GTEx Consortium