A gradient relationship between low birth weight and IQ: A meta-analysis.
A gradient relationship between low birth weight and IQ: A meta-analysis.
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DOI：
10.1038/s41598-017-18234-9
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发表时间：
2017-12-21
影响因子：
4.6
通讯作者：
Song R
中科院分区：
文献类型：
--
作者：
Gu H;Wang L;Liu L;Luo X;Wang J;Hou F;Nkomola PD;Li J;Liu G;Meng H;Zhang J;Song R
多项研究报告称，低出生体重者(LBW)的智商(IQ)低于正常出生体重者(Nbw，≥2500 g)。基于57项符合条件的个人研究，包括12,137名参与者，我们进行了一项荟萃分析，以估计低出生体重与个人智商得分(IQ)之间的关联。NBW和LBW智商的加权平均差(WMD)为10(95%可信区间为9.26~11.68)。无论年龄大小，WMD都是稳定的。未检测到发表偏倚。极低出生体重儿、极低出生体重儿、中低出生体重儿和正常出生体重者的平均智商分别为91、94、99和104 g，极低出生体重儿的平均智商为1,500~2 499 g，极低出生体重儿的平均智商为10 4，极低出生体重儿的平均智商为10 4。此外，智商与NBW相比，ELBW、VLBW和MLBW的WMD分别为14、10和7。两项研究允许估计社会健康决定因素对智商差异的影响，估计为13%。由于智商是遗传的，并受到环境因素的影响，父母的智商和其他因素导致了结果的残余混淆。由于这一结论是基于人口研究，它可能不适用于单一的个人。
Multiple studies have reported that individuals with low birth weights (LBW, <2500 g) have a lower intelligence quotient (IQ) than those with normal birth weights (NBW, ≥2500 g). Based on 57 eligible individual studies including 12,137 participants, we performed a meta-analysis to estimate the association between low birth weight and individuals’ IQ scores (IQs). The pooled weight mean difference (WMD) in IQs between NBW and LBW individuals was 10 (95% CI 9.26–11.68). The WMD was stable regardless of age. No publication bias was detected. The mean IQs of the extremely low birth weight (ELBW, <1000 g), very low birth weight (VLBW, 1000–1499 g), moderately low birth weight (MLBW, 1500–2499 g) and NBW individuals were 91, 94, 99 and 104, respectively. Additionally, the WMD in IQs with NBW were 14, 10 and 7 for ELBW, VLBW, and MLBW individuals, respectively. Two studies permitted estimates of the influence of social determinants of health to the discrepancy in IQs, which was 13%. Since IQ is inherited and influenced by environmental factors, parental IQs and other factors contribute to residual confounding of the results. As the conclusion was based on population studies, it may not be applicable to a single individual.
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影响因子：
2.5
作者：
Guarini, Annalisa;Sansavini, Alessandra;Karmiloff-Smith, Annette
通讯作者：
Karmiloff-Smith, Annette
影响因子：
1.9
作者：
Caldu, Xavier;Narberhaus, Ana;Botet, Francesc
通讯作者：
Botet, Francesc
影响因子：
120.7
作者：
Hack, M;Taylor, HG;Klein, N
通讯作者：
Klein, N
影响因子：
3.7
作者：
Cheong JL;Anderson PJ;Roberts G;Burnett AC;Lee KJ;Thompson DK;Molloy C;Wilson-Ching M;Connelly A;Seal ML;Wood SJ;Doyle LW
通讯作者：
Doyle LW
影响因子：
3.6
作者：
Aarnoudse-Moens, Cornelieke S. H.;Smidts, Diana P.;Weisglas-Kuperus, Nynke
通讯作者：
Weisglas-Kuperus, Nynke