Contribution of brain size to IQ and educational underperformance in extremely preterm adolescents.
Contribution of brain size to IQ and educational underperformance in extremely preterm adolescents.
复制标题
DOI：
10.1371/journal.pone.0077475
复制
发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Doyle LW
中科院分区：
文献类型：
--
作者：
Cheong JL;Anderson PJ;Roberts G;Burnett AC;Lee KJ;Thompson DK;Molloy C;Wilson-Ching M;Connelly A;Seal ML;Wood SJ;Doyle LW
与足月出生的同龄人相比，极早产儿的大脑更小，智商更低，学习成绩也更差。脑体积较小对EP的智商和教育劣势的影响尚不清楚。本研究旨在(i)比较EP出生（<28周）和足月出生（≥37周）的对照组青少年的多个脑组织和结构的脑容量，（ii）探索脑组织体积与智商和基本教育技能的关系，以及这是否因组而异，（iii）探索总脑组织体积在多大程度上解释了EP青少年与对照组相比表现不佳的原因。对1991-92年在澳大利亚维多利亚州出生的148名EP和132名足月对照进行纵向队列研究。在18岁时，计算磁共振成像确定的多个组织和结构的脑体积。智商和教育技能分别采用韦氏智力简略量表（WASI）和宽范围成就测验（WRAT-4）进行测量。与对照组相比，EP青少年的脑容量更小（脑组织总容量的平均差异[95%置信区间]为-5.9%[-8.0,-3.7%]）。最大的相对差异出现在丘脑和海马体。EP组的智商（-11.9[-15.4,-8.5]）、拼写（-8.0[-11.5,-4.6]）、数学计算（-10.3[-13.7,-6.9]）和单词阅读（-5.6[-8.8,-2.4]）得分低于对照组；所有的p值< 0.001。总的脑组织和其他脑组织和结构的体积与智商和教育技能呈正相关，这种关系在EP和对照组中都是相似的。总脑组织体积解释了EP和对照组之间20-40%的智商和教育结果差异。与对照组相比，EP青少年的脑容量更小，智商更低，学习成绩也更差。多个组织和结构的脑容量与智商和教育成果有关。脑组织总体积较小是EP出生的青少年认知和教育表现不佳的重要因素。
Extremely preterm (EP) survivors have smaller brains, lower IQ, and worse educational achievement than their term-born peers. The contribution of smaller brain size to the IQ and educational disadvantages of EP is unknown. This study aimed (i) to compare brain volumes from multiple brain tissues and structures between EP-born (<28weeks) and term-born (≥37weeks) control adolescents, (ii) to explore the relationships of brain tissue volumes with IQ and basic educational skills and whether this differed by group, and (iii) to explore how much total brain tissue volume explains the underperformance of EP adolescents compared with controls. Longitudinal cohort study of 148 EP and 132 term controls born in Victoria, Australia in 1991-92. At age 18, magnetic resonance imaging-determined brain volumes of multiple tissues and structures were calculated. IQ and educational skills were measured using the Wechsler Abbreviated Scale of Intelligence (WASI) and the Wide Range Achievement Test(WRAT-4), respectively. Brain volumes were smaller in EP adolescents compared with controls (mean difference [95% confidence interval] of -5.9% [-8.0, -3.7%] for total brain tissue volume). The largest relative differences were noted in the thalamus and hippocampus. The EP group had lower IQs(-11.9 [-15.4, -8.5]), spelling(-8.0 [-11.5, -4.6]), math computation(-10.3 [-13.7, -6.9]) and word reading(-5.6 [-8.8, -2.4]) scores than controls; all p-values<0.001. Volumes of total brain tissue and other brain tissues and structures correlated positively with IQ and educational skills, a relationship that was similar for both the EP and controls. Total brain tissue volume explained between 20-40% of the IQ and educational outcome differences between EP and controls. EP adolescents had smaller brain volumes, lower IQs and poorer educational performance than controls. Brain volumes of multiple tissues and structures are related to IQ and educational outcomes. Smaller total brain tissue volume is an important contributor to the cognitive and educational underperformance of adolescents born EP.
登录
查看更多内容
影响因子：
8
作者：
Doyle, LW
通讯作者：
Doyle, LW
影响因子：
3.8
作者：
Allin, M;Henderson, M;Murray, R
通讯作者：
Murray, R
影响因子：
5.2
作者：
Abernethy, LJ;Palaniappan, M;Cooke, RWI
通讯作者：
Cooke, RWI
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI
影响因子：
8
作者：
Saigal, S;den Ouden, L;Pinto-Martin, J
通讯作者：
Pinto-Martin, J