The effect of antibiotic usage on resistance in humans and food-producing animals: a longitudinal, One Health analysis using European data.

The effect of antibiotic usage on resistance in humans and food-producing animals: a longitudinal, One Health analysis using European data.
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DOI:
10.3389/fpubh.2023.1170426
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发表时间:
2023
影响因子:
5.2
通讯作者:
Hollis, Aidan
Hollis, Aidan
中科院分区:
医学3区
文献类型:
--
作者:
Rahman, Sakib;Hollis, Aidan

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本文评估了人类和食用动物中抗生素使用对人类和动物中人畜共患病细菌耐药性流行的影响。利用欧洲年度监测报告中关于耐药性和使用情况的全面纵向数据,我们发现食用动物中抗生素的使用和人类中抗生素的使用与人类和动物的耐药性流行率独立且因果相关。该研究考虑了人类和食用动物同时和全部使用抗生素,以确定使用对两组耐药性的边际效应和联合效应。通过采用滞后因变量和固定效应的规格,我们提供了一个下限和上限电阻的影响。这篇论文还有助于了解人类使用抗生素与其他动物耐药性之间的关系。
This paper estimates the effect of antibiotic usage in humans and food-producing animals on the prevalence of resistance in zoonotic bacteria in both humans and animals. Using comprehensive longitudinal data from annual surveillance reports on resistance and usage in Europe, we find that antibiotic usage in food-producing animals and antibiotic usage in humans are independently and causally related to the prevalence of resistance in both humans and animals. The study considers simultaneous and total usage of antibiotics in humans and food-producing animals to identify the marginal effects and joint effects of usage on resistance of both groups. By employing lagged-dependent variable and fixed-effects specifications, we provide a lower and an upper bound on the effects on resistance. The paper also contributes to the scant literature on how antibiotic use in humans is related to resistance in other animals.
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