Antimicrobial drug use and resistance in Europe.

Antimicrobial drug use and resistance in Europe.
复制标题

DOI:
10.3201/eid1411.070467
复制
发表时间:
2008-11
影响因子:
11.8
通讯作者:
Ferech, Matus
Ferech, Matus
中科院分区:
医学2区
文献类型:
--
作者:
de Sande-Bruinsma, Nienke Van;Grundmann, Hajo;Verloo, Didier;Tiemersma, Edine;Monen, Jos;Goossens, Herman;Ferech, Matus

文献摘要

参考文献

被引文献

相似文献

常规监测数据表明使用和耐药性之间的关系,并支持旨在减少欧洲国家一级抗菌剂消费的干预措施。我们的研究针对2000-2005年欧洲21个国家门诊护理中抗菌药的使用与两种主要病原体肺炎链球菌和大肠埃希菌的耐药性趋势,并探索抗菌药物使用决定耐药性的概念是否可以得到国家总体水平的监测数据的支持。从欧洲抗菌剂消费监测和欧洲抗菌素耐药性监测系统获得的数据表明,消费量的变化与国家一级出现抗药性的情况一致。线性回归分析表明,对于3种复合病原体组合中的2种,抗菌药的使用和耐药性之间的关联是特异和可靠的,随着时间的推移保持稳定,但不够敏感,不足以解释所有观察到的变化。基于常规监测数据的生态研究表明了使用和耐药性之间的关系,并支持旨在减少欧洲国家一级抗微生物药物消费的干预措施。
Routine surveillance data indicate a relation between use and resistance and support interventions designed to reduce antimicrobial consumption at a national level in Europe. Our study confronts the use of antimicrobial agents in ambulatory care with the resistance trends of 2 major pathogens, Streptococcus pneumoniae and Escherichia coli, in 21 European countries in 2000–2005 and explores whether the notion that antimicrobial drug use determines resistance can be supported by surveillance data at national aggregation levels. The data obtained from the European Surveillance of Antimicrobial Consumption and the European Antimicrobial Resistance Surveillance System suggest that variation of consumption coincides with the occurrence of resistance at the country level. Linear regression analysis showed that the association between antimicrobial drug use and resistance was specific and robust for 2 of 3 compound pathogen combinations, stable over time, but not sensitive enough to explain all of the observed variations. Ecologic studies based on routine surveillance data indicate a relation between use and resistance and support interventions designed to reduce antimicrobial drug consumption at a national level in Europe.
DOI: 10.1093/jac/dkh458
发表时间: 2004-12-01
影响因子: 5.2
作者:
Bruinsma, N;Kristinsson, KG;Grundmann, H
通讯作者: Grundmann, H
DOI: 10.3201/eid1009.040069
发表时间: 2004-09
影响因子: 11.8
作者:
Tiemersma EW;Bronzwaer SL;Lyytikäinen O;Degener JE;Schrijnemakers P;Bruinsma N;Monen J;Witte W;Grundman H;European Antimicrobial Resistance Surveillance System Participants
通讯作者: European Antimicrobial Resistance Surveillance System Participants
DOI: 10.1016/s0924-8579(03)00239-5
发表时间: 2003-11-01
影响因子: 10.8
作者:
García-Rey, C;Bouza, E;Baquero, F
通讯作者: Baquero, F
DOI: 10.3201/eid0812.010533
发表时间: 2002-12-01
影响因子: 11.8
作者:
Harbarth, S;Albrich, W;Brun-Buisson, C
通讯作者: Brun-Buisson, C
DOI: 10.1086/321848
发表时间: 2001-09-15
影响因子: 11.8
作者:
Steinke, D;Davey, P
通讯作者: Davey, P