Long-term avoidance memory formation is associated with a transient increase in mushroom body synaptic complexes in leaf-cutting ants.
Long-term avoidance memory formation is associated with a transient increase in mushroom body synaptic complexes in leaf-cutting ants.
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DOI：
10.3389/fnbeh.2015.00084
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发表时间：
2015
影响因子：
3
通讯作者：
Rössler W
中科院分区：
文献类型：
--
作者：
Falibene A;Roces F;Rössler W
与学习和经验相关的长期行为变化已被证明与大脑结构重塑有关。切叶蚁在被证明对共生真菌有害后学会避开以前喜欢的植物，这一过程涉及长期嗅觉记忆。我们研究了 Acromyrmex ambiguus 回避学习后长期嗅觉记忆形成后大脑微结构变化的动态。在进行实验来控制与年龄和体型相关的可能的神经元变化后，我们在学习后的不同时间量化了蘑菇体（MB）嗅觉区域的突触复合体（微肾小球，MG）。长期回避记忆的形成与 MG 密度的短暂变化有关。学习两天后，MG密度比学习前更高。在学习后的第 4 天和第 15 天，当蚂蚁仍然表现出植物回避时，MG 密度已降至初始状态。由长期回避记忆形成引发的MG结构重组明显不同于纯粹接触和收集具有独特气味的新植物所促进的变化。同时收集几种（而不是一种）无害植物物种的感官暴露导致嗅唇中 MG 密度的降低。我们假设，虽然感觉暴露导致 MB 嗅唇中的 MG 修剪，但长期回避记忆的形成涉及新 MG 的初始生长，然后是随后的修剪。
Long-term behavioral changes related to learning and experience have been shown to be associated with structural remodeling in the brain. Leaf-cutting ants learn to avoid previously preferred plants after they have proved harmful for their symbiotic fungus, a process that involves long-term olfactory memory. We studied the dynamics of brain microarchitectural changes after long-term olfactory memory formation following avoidance learning in Acromyrmex ambiguus. After performing experiments to control for possible neuronal changes related to age and body size, we quantified synaptic complexes (microglomeruli, MG) in olfactory regions of the mushroom bodies (MBs) at different times after learning. Long-term avoidance memory formation was associated with a transient change in MG densities. Two days after learning, MG density was higher than before learning. At days 4 and 15 after learning—when ants still showed plant avoidance—MG densities had decreased to the initial state. The structural reorganization of MG triggered by long-term avoidance memory formation clearly differed from changes promoted by pure exposure to and collection of novel plants with distinct odors. Sensory exposure by the simultaneous collection of several, instead of one, non-harmful plant species resulted in a decrease in MG densities in the olfactory lip. We hypothesize that while sensory exposure leads to MG pruning in the MB olfactory lip, the formation of long-term avoidance memory involves an initial growth of new MG followed by subsequent pruning.
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影响因子：
2.5
作者：
Frambach, I;Rössler, W;Schürmann, FW
通讯作者：
Schürmann, FW
影响因子：
1.9
作者：
Camargo, R. S.;Forti, L. C.;Ottati, A. L. T.
通讯作者：
Ottati, A. L. T.
影响因子：
2.5
作者：
Julian, GE;Fewell, JH
通讯作者：
Fewell, JH
DOI：
10.1073/pnas.0400773101
发表时间：
2004-03-23
影响因子：
11.1
作者：
Groh, C;Tautz, J;Rössler, W
通讯作者：
Rössler, W
影响因子：
2
作者：
Groh, Claudia;Roessler, Wolfgang
通讯作者：
Roessler, Wolfgang