Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa.

Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa.
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DOI:
10.1038/mi.2009.100
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发表时间:
2009-09
期刊:
影响因子:
8
通讯作者:
--
中科院分区:
医学1区
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--
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辅助性T细胞17(Th17)是一种独特的T细胞谱系,可产生效应分子IL-17、IL-17F、IL-21和IL-22。尽管Th17细胞在自身免疫中的作用已经得到了很好的证明,但越来越多的证据表明,Th17谱系和其他产生IL-17的细胞对于宿主防御粘膜表面的细菌、真菌和病毒感染至关重要。在这里,我们总结了我们对IL-17产生细胞作为天然免疫和获得性免疫之间的桥梁作用的最新进展,以对抗粘膜上的传染病。
T helper type 17 (Th17) cells are a distinct lineage of T cells that produce the effector molecules IL-17, IL-17F, IL-21 and IL-22. Although the role of Th17 cells in autoimmunity is well documented, there is growing evidence that the Th17 lineage and other IL-17 producing cells are critical for host defense against bacterial, fungal and viral infections at mucosal surfaces. Here we summarize recent progress in our understanding of the function of IL-17 producing cells as a bridge between innate and adaptive immunity against infectious diseases at the mucosa.
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