Down regulation of E-Cadherin (ECAD) - a predictor for occult metastatic disease in sentinel node biopsy of early squamous cell carcinomas of the oral cavity and oropharynx.
Down regulation of E-Cadherin (ECAD) - a predictor for occult metastatic disease in sentinel node biopsy of early squamous cell carcinomas of the oral cavity and oropharynx.
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下调E-钙粘蛋白（ECAD） - 在口腔和口咽早期鳞状细胞癌的前哨淋巴结活检中，神秘转移性疾病的预测因子。
DOI：
10.1186/1471-2407-11-217
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发表时间：
2011-06-03
期刊：
影响因子：
3.8
通讯作者：
Stoeckli SJ
中科院分区：
文献类型：
--
作者：
Huber GF;Züllig L;Soltermann A;Roessle M;Graf N;Haerle SK;Studer G;Jochum W;Moch H;Stoeckli SJ
预测头颈部鳞状细胞癌（HNSCC）患者隐匿性淋巴结转移的预后因素对于改善这种肿瘤类型的前哨淋巴结手术的结果是必要的。E-Cadherin糖蛋白是上皮细胞内的一种细胞间粘附分子，在细胞间连接的建立和维持中起重要作用。探讨E-Cadherin在预测乳腺癌局部转移中的价值。应用组织芯片技术检测120例口腔、口咽部鳞状细胞癌组织中E-钙粘蛋白的表达。肿瘤位于口腔110例（91.7%），以舌为主，口咽部10例（8.3%）。通过强度反应性评分（IRS）定量E-钙粘蛋白表达的强度。这些结果与前哨淋巴结活检的淋巴结状态相关。单变量和多变量分析用于确定统计学显著性。pT分期、性别、肿瘤侧别、部位与淋巴结转移无关。在单变量和多变量分析中，分化级别（p = 0.018）和E-Cadherin表达下调与阳性淋巴结状态（p = 0.005）显著相关。这些数据表明E-cadherin表达的缺失与HNSCC的异质性转移增加相关。E-cadherin免疫组化可作为预测口腔及口咽鳞癌淋巴结转移的指标。证据等级：2b
Prognostic factors in predicting occult lymph node metastasis in patients with head and neck squamous-cell carcinoma (HNSCC) are necessary to improve the results of the sentinel lymph node procedure in this tumour type. The E-Cadherin glycoprotein is an intercellular adhesion molecule in epithelial cells, which plays an important role in establishing and maintaining intercellular connections. To determine the value of the molecular marker E-Cadherin in predicting regional metastatic disease. E-Cadherin expression in tumour tissue of 120 patients with HNSCC of the oral cavity and oropharynx were evaluated using the tissue microarray technique. 110 tumours were located in the oral cavity (91.7%; mostly tongue), 10 tumours in the oropharynx (8.3%). Intensity of E-Cadherin expression was quantified by the Intensity Reactivity Score (IRS). These results were correlated with the lymph node status of biopsied sentinel lymph nodes. Univariate and multivariate analysis was used to determine statistical significance. pT-stage, gender, tumour side and location did not correlate with lymph node metastasis. Differentiation grade (p = 0.018) and down regulation of E-Cadherin expression significantly correlate with positive lymph node status (p = 0.005) in univariate and multivariate analysis. These data suggest that loss of E-cadherin expression is associated with increased lymhogeneous metastasis of HNSCC. E-cadherin immunohistochemistry may be used as a predictor for lymph node metastasis in squamous cell carcinoma of the oral cavity and oropharynx. Level of evidence: 2b
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影响因子：
6.4
作者：
Albinger-Hegyi, Andrea;Stoeckli, Sandro J.;Hegyi, Ivan
通讯作者：
Hegyi, Ivan
影响因子：
254.7
作者：
Landis, SH;Murray, T;Wingo, PA
通讯作者：
Wingo, PA
影响因子：
82.9
作者：
Kononen, J;Bubendorf, L;Kallioniemi, OP
通讯作者：
Kallioniemi, OP
影响因子：
21.3
作者：
Ma, Li;Young, Jennifer;Prabhala, Harsha;Pan, Elizabeth;Mestdagh, Pieter;Muth, Daniel;Teruya-Feldstein, Julie;Reinhardt, Ferenc;Onder, Tamer T.;Valastyan, Scott;Westermann, Frank;Speleman, Frank;Vandesompele, Jo;Weinberg, Robert A.
通讯作者：
Weinberg, Robert A.
影响因子：
3.7
作者：
Goerkem, Mete;Braun, Julia;Stoeckli, Sandro J.
通讯作者：
Stoeckli, Sandro J.