Effects of high-dose isoflavones on metabolic and inflammatory markers in healthy postmenopausal women.
Effects of high-dose isoflavones on metabolic and inflammatory markers in healthy postmenopausal women.
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DOI：
10.1097/gme.0b013e3181857979
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发表时间：
2009-03
期刊：
影响因子：
--
通讯作者：
Basaria S
中科院分区：
文献类型：
--
作者：
Charles C;Yuskavage J;Carlson O;John M;Tagalicud AS;Maggio M;Muller DC;Egan J;Basaria S
更年期后，女性的身体成分会发生变化，尤其是脂肪量的增加。此外，年龄增长、体力活动减少和炎症增加可能使他们容易患上 2 型糖尿病。异黄酮已被证明可以改善绝经后妇女的代谢参数。然而，异黄酮对脂肪细胞因子的影响仍不清楚。评估高剂量异黄酮对绝经后女性炎症和代谢标志物的影响。我们测量了 75 名健康绝经后女性的葡萄糖、胰岛素和脂肪因子/细胞因子，这些女性被随机分配接受 20 克大豆蛋白和 160 毫克总异黄酮（64 毫克染料木黄酮、63 毫克二黄酮、34 毫克黄豆黄素）或 20 克大豆蛋白安慰剂，为期 12 周。服用雌激素的女性在研究前至少三个月停止治疗。这些补充剂以粉末形式提供，每天与牛奶或其他饮料一起服用一次。安慰剂组和活性组的平均年龄相似 (p=0.4)。绝经后的平均时间为 9 年，三分之二的女性经历了自然绝经。各组之间的基线 BMI 没有显着差异 [安慰剂 (25.1 kg/m2)，活性组 (26 kg/m2)]，并且在研究期间没有显着变化。在基线时，安慰剂组的 TNF-α 水平显着较高（p<0.0001），否则任何其他参数都没有差异。治疗 12 周后，安慰剂组的 TNF-α 水平（p<0.0001）和异黄酮组的脂联素水平（p=0.03）出现显着的正向变化。比较各组之间的前后变化表明，与安慰剂相比，异黄酮组的血清脂联素水平虽小但显着增加（p = 0.03）。两组之间的任何其他参数均未发现显着变化。健康、体重正常的绝经后女性在服用高剂量异黄酮时，尽管血清脂联素水平有所增加，但代谢参数可能不会得到改善。异黄酮对肥胖和胰岛素抵抗的绝经后妇女的作用需要探索。
After menopause, women experience changes in body composition, especially increase in fat mass. Additionally, advancing age, decreased physical activity and increased inflammation may predispose them to develop type-2 diabetes. Isoflavones have been shown to improve metabolic parameters in postmenopausal women. However, the effect of isoflavones on adipo-cytokines remains unclear. To evaluate the effect of high dose isoflavones on inflammatory and metabolic markers in postmenopausal women. We measured glucose, insulin and adipokines/cytokines in 75 healthy postmenopausal women who were randomized to receive 20 gm of soy protein with 160 mg of total isoflavones (64mg genistein, 63 mg diadzein, 34 mg glycitein) or 20 gm of soy protein placebo for 12 weeks. Women on estrogen discontinued therapy at least three months prior to the study. The supplements were given in a powder form and consumed once daily with milk or other beverages. Mean age in the placebo and active groups was similar (p=0.4). Average time since menopause was 9 yrs and two-thirds of the women underwent natural menopause. There was no significant difference in the BMI at baseline between the groups [placebo (25.1 kg/m2), active (26 kg/m2)] and it did not change significantly during the study. At baseline, placebo group had significantly higher levels of TNF-α (p<0.0001), otherwise there was no difference in any other parameter. After 12 weeks of treatment, there were significant positive changes in TNF-α levels within the placebo group (p<0.0001) and adiponectin levels within the isoflavones group (p=0.03). Comparison of pre-post change between the groups showed a small but significant increase in serum adiponectin levels in the isoflavone group (p=0.03) compared to placebo. No significant changes were seen in any other parameter between the two groups. Healthy, normal-weight postmenopausal women may not experience improvement in metabolic parameters when given high dose isoflavones despite an increase in serum adiponectin levels. Role of isoflavones in obese and insulin resistant postmenopausal women needs exploration.
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影响因子：
16.2
作者：
Brown, MD;Korytkowski, MT;Hagberg, JM
通讯作者：
Hagberg, JM
影响因子：
5.8
作者：
Nikander, E;Tiitinen, A;Ylikorkala, O
通讯作者：
Ylikorkala, O
影响因子：
5.8
作者：
Andersson, B;Mattsson, LA;Bjorntorp, P
通讯作者：
Bjorntorp, P
影响因子：
8.2
作者：
MATTHEWS, DR;HOSKER, JP;TURNER, RC
通讯作者：
TURNER, RC
影响因子：
5.1
作者：
FUJIMOTO, WY;BERGSTROM, RW;WAHL, PW
通讯作者：
WAHL, PW