25th anniversary article: Rational design and applications of hydrogels in regenerative medicine.
25th anniversary article: Rational design and applications of hydrogels in regenerative medicine.
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DOI：
10.1002/adma.201303233
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发表时间：
2014-01-08
影响因子：
29.4
通讯作者：
Khademhosseini, Ali
中科院分区：
文献类型：
--
作者：
Annabi, Nasim;Tamayol, Ali;Uquillas, Jorge Alfredo;Akbari, Mohsen;Bertassoni, Luiz E.;Cha, Chaenyung;Camci-Unal, Gulden;Dokmeci, Mehmet R.;Peppas, Nicholas A.;Khademhosseini, Ali
水凝胶是基于亲水性聚合物的材料，具有高含水量和类似于天然细胞外基质的物理特性。由于其显著的性质，水凝胶系统用于广泛的生物医学应用，例如用于组织工程的三维（3D）基质、药物递送载体、复合生物材料，以及作为微创手术中的可注射填充剂。此外，具有受控物理和生物学性质的水凝胶的合理设计可用于调节细胞功能和组织形态发生。在这里，先进的水凝胶与可调的理化性能的发展是突出的，特别强调弹性体，光敏，复合材料和形状记忆水凝胶。还讨论了过去十年开发的控制水凝胶结构的新兴技术，并回顾了水凝胶在再生医学中利用的许多潜在应用和挑战。预计复杂水凝胶的持续发展将导致临床应用，从而改善患者护理和生活质量。
Hydrogels are hydrophilic polymer-based materials with high water content and physical characteristics that resemble the native extracellular matrix. Because of their remarkable properties, hydrogel systems are used for a wide range of biomedical applications, such as three-dimensional (3D) matrices for tissue engineering, drug-delivery vehicles, composite biomaterials, and as injectable fillers in minimally invasive surgeries. In addition, the rational design of hydrogels with controlled physical and biological properties can be used to modulate cellular functionality and tissue morphogenesis. Here, the development of advanced hydrogels with tunable physiochemical properties is highlighted, with particular emphasis on elastomeric, light-sensitive, composite, and shape-memory hydrogels. Emerging technologies developed over the past decade to control hydrogel architecture are also discussed and a number of potential applications and challenges in the utilization of hydrogels in regenerative medicine are reviewed. It is anticipated that the continued development of sophisticated hydrogels will result in clinical applications that will improve patient care and quality of life.
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影响因子：
14
作者：
Aubin H;Nichol JW;Hutson CB;Bae H;Sieminski AL;Cropek DM;Akhyari P;Khademhosseini A
通讯作者：
Khademhosseini A
影响因子：
19
作者：
Agarwal A;Farouz Y;Nesmith AP;Deravi LF;McCain ML;Parker KK
通讯作者：
Parker KK
影响因子：
14
作者：
Annabi, Nasim;Mithieux, Suzanne M.;Dehghani, Fariba
通讯作者：
Dehghani, Fariba
影响因子：
6.1
作者：
Albrecht, DR;Tsang, VL;Bhatia, SN
通讯作者：
Bhatia, SN
影响因子：
29.4
作者：
Adams, Jacob J.;Duoss, Eric B.;Lewis, Jennifer A.
通讯作者：
Lewis, Jennifer A.