Insular functional organization during handgrip in females and males with obstructive sleep apnea.
Insular functional organization during handgrip in females and males with obstructive sleep apnea.
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DOI：
10.1371/journal.pone.0246368
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Macey PM
中科院分区：
文献类型：
--
作者：
Pal A;Ogren JA;Aysola RS;Kumar R;Henderson LA;Harper RM;Macey PM
阻塞性睡眠呼吸暂停（OSA）患者自主神经功能的大脑调节以性别特异性方式被破坏，包括在睡眠呼吸暂停中，这可能导致几种合并症。岛叶脑回在自主神经系统调节方面具有解剖学上不同的功能;然而，OSA对自主神经挑战的交感神经成分的岛叶脑回反应的组织几乎没有影响，Valsalva。我们进一步评估了阻塞性睡眠呼吸暂停患者的岛叶脑回对静态握力任务的神经反应，该任务主要涉及副交感神经的退缩。采用血氧水平依赖性功能磁共振成像（fMRI）检测胰岛功能。我们研究了48例新诊断的OSA（平均年龄±标准差：46.5±9岁; AHI±标准差：32.6±21.1次事件/小时; 36例男性）和63例健康受试者（47.2±8.8岁;40例男性）。受试者在扫描过程中进行了4次16秒的手柄（间隔1分钟，80%主观最大强度）。在组合和单独的女性-男性模型中，通过重复测量ANOVA（p<0.05）评估了5个岛叶脑回-前短（ASG）、中短（MSG）、后短（PSG）、前长（ALG）和后长（PLG）-的fMRI时间趋势的组内反应和组间差异;还评估了年龄和静息心率（HR）的影响。女性表现出更大的右前优势，在ASG，但没有出现差异OSA和控制之间的相关功能组织的手握。男性在ASG表现出更大的左前优势，但OSA和对照组之间也没有差异。男性仅在ALG中显示出OSA和对照组之间的组差异。与对照组相比，OSA组男性在ALG的左侧激活较低。反应主要受HR和年龄的影响;然而，年龄并不影响女性右前优势的反应。岛叶回功能反应的手柄不同，在OSA与对照组的性别为基础的方式，但仅在一侧的回，这表明在交感神经激活，但副交感神经撤回的前部和右侧岛占主导地位，在很大程度上是完整的，尽管形态损伤的整体结构。
Brain regulation of autonomic function in obstructive sleep apnea (OSA) is disrupted in a sex-specific manner, including in the insula, which may contribute to several comorbidities. The insular gyri have anatomically distinct functions with respect to autonomic nervous system regulation; yet, OSA exerts little effect on the organization of insular gyral responses to sympathetic components of an autonomic challenge, the Valsalva. We further assessed neural responses of insular gyri in people with OSA to a static handgrip task, which principally involves parasympathetic withdrawal. We measured insular function with blood oxygen level dependent functional MRI. We studied 48 newly-diagnosed OSA (age mean±std:46.5±9 years; AHI±std:32.6±21.1 events/hour; 36 male) and 63 healthy (47.2±8.8 years;40 male) participants. Subjects performed four 16s handgrips (1 min intervals, 80% subjective maximum strength) during scanning. fMRI time trends from five insular gyri—anterior short (ASG); mid short (MSG); posterior short (PSG); anterior long (ALG); and posterior long (PLG)—were assessed for within-group responses and between-group differences with repeated measures ANOVA (p<0.05) in combined and separate female-male models; age and resting heart-rate (HR) influences were also assessed. Females showed greater right anterior dominance at the ASG, but no differences emerged between OSA and controls in relation to functional organization of the insula in response to handgrip. Males showed greater left anterior dominance at the ASG, but there were also no differences between OSA and controls. The males showed a group difference between OSA and controls only in the ALG. OSA males had lower left activation at the ALG compared to control males. Responses were mostly influenced by HR and age; however, age did not impact the response for right anterior dominance in females. Insular gyri functional responses to handgrip differ in OSA vs controls in a sex-based manner, but only in laterality of one gyrus, suggesting anterior and right-side insular dominance during sympathetic activation but parasympathetic withdrawal is largely intact, despite morphologic injury to the overall structure.
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影响因子：
4.5
作者：
GALLO, L;MACIEL, BC;MANCO, JC
通讯作者：
MANCO, JC
影响因子：
5.5
作者：
GANDEVIA, SC;HOBBS, SF
通讯作者：
HOBBS, SF
影响因子：
2.5
作者：
Han, Su-Hyun;Kim, Hyo Jae;Lee, Sang-Ahm
通讯作者：
Lee, Sang-Ahm
DOI：
10.1002/ar.22513
发表时间：
2012-09-01
影响因子：
2
作者：
Henderson, Luke A.;James, Cheree;Macefield, Vaughan G.
通讯作者：
Macefield, Vaughan G.
影响因子：
5.6
作者：
Faux, MD;Larkin, EK;Redline, S
通讯作者：
Redline, S