Motor abnormalities, depression risk, and clinical course in adolescence.
Motor abnormalities, depression risk, and clinical course in adolescence.
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DOI：
10.1016/j.bpsgos.2021.06.011
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发表时间：
2022-01
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影响因子：
--
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中科院分区：
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运动异常，如精神运动性躁动和发育迟缓，被广泛认为是抑郁症的核心特征。然而，目前尚不清楚运动异常是否意味着抑郁症的风险。利用青少年大脑认知发展（ABCD）研究的数据，一项具有全国代表性的青少年样本（N = 10,835, 9-11岁），本论文探讨了运动异常是否与1)青春期早期抑郁症状，2)家族抑郁风险（家族风险负荷）以及3)未来抑郁症状相关。运动异常测量包括传统的（DSM）运动体征，如精神运动激动和迟缓，以及其他运动领域，如发育性运动迟缓和协调障碍。在青少年中，传统运动异常（躁动= 3.2%，发育迟缓= 0.3%）比非传统运动领域（发育迟缓= 13.79%，协调能力= 35.5%）更少见。运动功能障碍与抑郁症状相关（Cohen’s d = 0.02 ~ 0.12）。抑郁症的家族性风险与运动异常有关（Cohen’s d = 0.08 ~ 0.27），但运动发育迟缓除外。家庭脆弱性对抑郁风险的敏感性各不相同（例如，发育迟缓：0.53%；协调障碍：32.05%）。在1年的随访中，运动异常的基线背书预测了未来的抑郁症状。这些发现表明，运动信号反映了一种新的、有希望的未来方向，即研究青春期早期易患抑郁症的风险。
Motor abnormalities, such as psychomotor agitation and retardation, are widely recognized as core features of depression. However, it is not currently known whether motor abnormalities connote risk for depression. Using data from the Adolescent Brain Cognitive Development (ABCD) Study, a nationally representative sample of youth (N = 10,835, 9–11 years old), the present paper examines whether motor abnormalities are associated with 1) depression symptoms in early adolescence, 2) familial risk for depression (familial risk loading), and 3) future depression symptoms. Motor abnormality measures included traditional (DSM) motor signs such as psychomotor agitation and retardation as well as other motor domains such as developmental motor delays and dyscoordination. Traditional motor abnormalities were less prevalent (agitation = 3.2%, retardation = 0.3%) than nontraditional domains (delays = 13.79%, coordination = 35.5%) among adolescents. Motor dysfunction was associated with depression symptoms (Cohen’s d = 0.02 to 0.12). Familial risk for depression was related to motor abnormalities (Cohen’s d = 0.08 to 0.27), with the exception of motor retardation. Family vulnerability varied in sensitivity to depression risk (e.g., retardation: 0.53%; dyscoordination: 32.05%). Baseline endorsement of motor abnormalities predicted future depression symptoms at 1-year follow-up. These findings suggest that motor signs reflect a novel, promising future direction for examining vulnerability to depression risk in early adolescence.
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影响因子：
3.7
作者：
Bracht T;Federspiel A;Schnell S;Horn H;Höfle O;Wiest R;Dierks T;Strik W;Müller TJ;Walther S
通讯作者：
Walther S
影响因子：
2.1
作者：
Cornish, AM;McMahon, CA;Tennant, C
通讯作者：
Tennant, C
DOI：
10.3390/ejihpe10020048
发表时间：
2020-06-01
影响因子：
3.2
作者：
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通讯作者：
Caldwell, Cleopatra H.
影响因子：
5.5
作者：
Avenevoli, Shelli;Ries Merikangas, Kathleen
通讯作者：
Ries Merikangas, Kathleen
影响因子：
3.3
作者：
Hill, Elisabeth L.;Brown, Duncan
通讯作者：
Brown, Duncan