Cortico-cortical white matter motor pathway microstructure is related to psychomotor retardation in major depressive disorder.
Cortico-cortical white matter motor pathway microstructure is related to psychomotor retardation in major depressive disorder.
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DOI：
10.1371/journal.pone.0052238
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Walther S
中科院分区：
文献类型：
--
作者：
Bracht T;Federspiel A;Schnell S;Horn H;Höfle O;Wiest R;Dierks T;Strik W;Müller TJ;Walther S
脑结构和功能的改变与重度抑郁症（MDD）的精神运动迟缓有关。然而，运动行为和运动通路白质完整性在MDD中的关联尚不清楚。本研究的目的是首先研究MDD中白质运动通路的结构连通性。其次，我们探讨了客观测量的运动活动与MDD运动通路白质完整性的关系。因此，21名重度抑郁症患者和21名年龄、性别、受教育程度和体重指数相匹配的健康对照者在同一天接受了弥散张量成像和24小时活动记录仪（测量活动水平）。应用概率纤维跟踪方法，我们提取了背外侧前额叶皮层（dlPFC）、吻侧前扣带皮层（rACC）、前辅助运动区（pre-SMA）、SMA-proper、初级运动皮层（M1）、尾状核、壳核、白球和丘脑之间的连接通路。患者的活动水平较低，并且在连接左sma前和SMA-proper，以及右SMA-proper和M1的通路中显示出增加的平均弥漫性（MD）。探索性分析指出，MDD患者右racc -前sma连接的活动水平和平均分数各向异性呈正相关。只有低活动水平的重度抑郁症患者在左dlpfc -前sma连接中活动水平和平均md呈负线性相关。我们的研究结果指出了MDD中皮质-皮质白质运动通路的结构改变。rACC-pre-SMA和dlPFC-pre-SMA通路白质组织的改变可能有助于MDD的运动启动。
Alterations of brain structure and function have been associated with psychomotor retardation in major depressive disorder (MDD). However, the association of motor behaviour and white matter integrity of motor pathways in MDD is unclear. The aim of the present study was to first investigate structural connectivity of white matter motor pathways in MDD. Second, we explore the relation of objectively measured motor activity and white matter integrity of motor pathways in MDD. Therefore, 21 patients with MDD and 21 healthy controls matched for age, gender, education and body mass index underwent diffusion tensor imaging and 24 hour actigraphy (measure of the activity level) the same day. Applying a probabilistic fibre tracking approach we extracted connection pathways between the dorsolateral prefrontal cortex (dlPFC), the rostral anterior cingulate cortex (rACC), the pre-supplementary motor area (pre-SMA), the SMA-proper, the primary motor cortex (M1), the caudate nucleus, the putamen, the pallidum and the thalamus. Patients had lower activity levels and demonstrated increased mean diffusivity (MD) in pathways linking left pre-SMA and SMA-proper, and right SMA-proper and M1. Exploratory analyses point to a positive association of activity level and mean-fractional anisotropy in the right rACC-pre-SMA connection in MDD. Only MDD patients with low activity levels had a negative linear association of activity level and mean-MD in the left dlPFC-pre-SMA connection. Our results point to structural alterations of cortico-cortical white matter motor pathways in MDD. Altered white matter organisation of rACC-pre-SMA and dlPFC-pre-SMA pathways may contribute to movement initiation in MDD.
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影响因子：
3.1
作者：
Groenewegen HJ
通讯作者：
Groenewegen HJ
影响因子：
15.9
作者：
Der-Avakian A;Markou A
通讯作者：
Markou A
DOI：
10.1523/jneurosci.0895-11.2011
发表时间：
2011-07-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Ballard IC;Murty VP;Carter RM;MacInnes JJ;Huettel SA;Adcock RA
通讯作者：
Adcock RA
影响因子：
3.7
作者：
Blood AJ;Iosifescu DV;Makris N;Perlis RH;Kennedy DN;Dougherty DD;Kim BW;Lee MJ;Wu S;Lee S;Calhoun J;Hodge SM;Fava M;Rosen BR;Smoller JW;Gasic GP;Breiter HC;Phenotype Genotype Project on Addiction and Mood Disorders
通讯作者：
Phenotype Genotype Project on Addiction and Mood Disorders
影响因子：
3.3
作者：
Deoni, Sean C. L.;Rutt, Brian K.;Jones, Derek K.
通讯作者：
Jones, Derek K.