Pax6 loss alters the morphological and electrophysiological development of mouse prethalamic neurons.
Pax6 loss alters the morphological and electrophysiological development of mouse prethalamic neurons.
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DOI：
10.1242/dev.200052
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发表时间：
2022-03-15
期刊：
影响因子：
--
通讯作者：
Price DJ
中科院分区：
文献类型：
--
作者：
Tian T;Quintana-Urzainqui I;Kozić Z;Pratt T;Price DJ
Pax6 is a well-known regulator of early neuroepithelial progenitor development. Its constitutive loss has a particularly strong effect on the developing prethalamus, causing it to become extremely hypoplastic. To overcome this difficulty in studying the long-term consequences of Pax6 loss for prethalamic development, we used conditional mutagenesis to delete Pax6 at the onset of neurogenesis and studied the developmental potential of the mutant prethalamic neurons in vitro. We found that Pax6 loss affected their rates of neurite elongation, the location and length of their axon initial segments, and their electrophysiological properties. Our results broaden our understanding of the long-term consequences of Pax6 deletion in the developing mouse forebrain, suggesting that it can have cell-autonomous effects on the structural and functional development of some neurons. Summary: Pax6 impacts neurite extension, axon initial segment properties and the ability to fire normal action potentials in maturing neurons, revealing actions extending beyond those previously characterised in progenitors.
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影响因子：
5.3
作者：
Höfflin F;Jack A;Riedel C;Mack-Bucher J;Roos J;Corcelli C;Schultz C;Wahle P;Engelhardt M
通讯作者：
Engelhardt M
影响因子：
8.8
作者：
Caballero IM;Manuel MN;Molinek M;Quintana-Urzainqui I;Mi D;Shimogori T;Price DJ
通讯作者：
Price DJ
DOI：
10.1523/jneurosci.4064-11.2011
发表时间：
2011-11-09
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Grubb MS;Shu Y;Kuba H;Rasband MN;Wimmer VC;Bender KJ
通讯作者：
Bender KJ
影响因子：
25
作者：
Kole, Maarten H. P.;Stuart, Greg J.
通讯作者：
Stuart, Greg J.
影响因子：
3.4
作者：
Cvekl, Ales;Callaerts, Patrick
通讯作者：
Callaerts, Patrick