Atypical Functional Connectivity of Amygdala Related to Reduced Symptom Severity in Children With Autism.
Atypical Functional Connectivity of Amygdala Related to Reduced Symptom Severity in Children With Autism.
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DOI：
10.1016/j.jaac.2018.06.015
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发表时间：
2018-10
影响因子：
13.3
通讯作者：
Müller RA
中科院分区：
文献类型：
--
作者：
Fishman I;Linke AC;Hau J;Carper RA;Müller RA
越来越多的证据表明，自闭症谱系障碍（ASD）的大脑异常涉及非典型的网络连接。鉴于社交缺陷在ASD表型中的核心作用，本研究检查了患有ASD的儿童和青少年的杏仁核（一种重要参与社会信息处理的大脑结构）的功能连接，以及年龄依赖性变化和与临床症状的联系。静息状态功能磁共振成像（rs-fMRI）数据，从55名参与者与ASD和50个典型的发展（TD）控制，年龄7-17岁，被纳入。各组在年龄、性别、智商和头部运动方面相匹配。应用功能连接MRI（fcMRI）分析来检查杏仁核的内在功能连接（iFC），包括年龄相关变化的横断面测试。直接组间比较显示，减少双边杏仁核和左下枕叶皮质之间的功能连接，伴随着更大的连接右杏仁核和右感觉运动皮质在ASD组。这种杏仁核连接的非典型模式与症状严重程度降低和整体功能改善相关，特别是在具有最不典型杏仁核iFC但社会功能受损最少的ASD亚组中观察到。在TD组中观察到的杏仁核-前额叶连接性的增强，在ASD儿童中没有检测到。研究结果支持异常的网络雕刻在自闭症，特别是杏仁核和初级感觉运动电路之间的非典型整合。非典型iFC和行为测量之间的特殊联系表明，异常的杏仁核功能连接可能是补偿在一些个体与ASD。
Converging evidence indicates that brain abnormalities in autism spectrum disorders (ASDs) involve atypical network connectivity. Given the central role of social deficits in the ASD phenotype, this investigation examined functional connectivity of the amygdala – a brain structure critically involved in processing of social information – in children and adolescents with ASDs, as well as age-dependent changes and links with clinical symptoms. Resting-state functional magnetic resonance imaging (rs-fMRI) data from 55 participants with ASDs and 50 typically developing (TD) controls, ages 7–17 years, were included. Groups were matched for age, gender, IQ, and head motion. Functional connectivity MRI (fcMRI) analysis was applied to examine intrinsic functional connectivity (iFC) of the amygdala, including cross-sectional tests of age-related changes. Direct between-group comparisons revealed reduced functional connectivity between bilateral amygdalae and left inferior occipital cortex, accompanied by greater connectivity between right amygdala and right sensorimotor cortex in the ASD group. This atypical pattern of amygdala connectivity was associated with decreased symptom severity and better overall functioning, as specifically seen in an ASD subgroup with the most atypical amygdala iFC but least impaired social functioning. Age-related strengthening of amygdala-prefrontal connectivity, as observed in the TD group, was not detected in children with ASDs. Findings support aberrant network sculpting in ASDs, specifically atypical integration between amygdala and primary sensorimotor circuits. Paradoxical links between atypical iFC and behavioral measures suggest that abnormal amygdala functional connections may be compensatory in some individuals with ASDs.
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社会大脑：社会知识的神经基础。
影响因子：
24.8
作者：
Adolphs, Ralph
通讯作者：
Adolphs, Ralph
影响因子：
25.8
作者：
Fishman, Irina;Keown, Christopher L.;Lincoln, Alan J.;Pineda, Jaime A.;Mueller, Ralph-Axel
通讯作者：
Mueller, Ralph-Axel
DOI：
10.1098/rstb.2006.2003
发表时间：
2007-04-29
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
--
作者：
Frith CD
通讯作者：
Frith CD
影响因子：
2.5
作者：
Freese, JL;Amaral, DG
通讯作者：
Amaral, DG
探索人类大脑功能的科学
DOI：
10.1073/pnas.0911855107
发表时间：
2010-03-09
影响因子：
11.1
作者：
Biswal, Bharat B.;Mennes, Maarten;Milham, Michael P.
通讯作者：
Milham, Michael P.