Atypical cross talk between mentalizing and mirror neuron networks in autism spectrum disorder.
Atypical cross talk between mentalizing and mirror neuron networks in autism spectrum disorder.
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DOI：
10.1001/jamapsychiatry.2014.83
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发表时间：
2014-07-01
期刊：
影响因子：
25.8
通讯作者：
Mueller, Ralph-Axel
中科院分区：
文献类型：
--
作者：
Fishman, Irina;Keown, Christopher L.;Lincoln, Alan J.;Pineda, Jaime A.;Mueller, Ralph-Axel
越来越多的证据表明，自闭症谱系障碍（ASD）的大脑异常涉及非典型的网络连接，但目前还不清楚改变的连接是否在参与社会认知的大脑网络中特别突出。目的探讨青少年ASD患者的心理理论（ToM）和镜像神经元系统（MNS）这两个涉及社会加工的脑网络是否存在功能连接的改变。采用静息态功能磁共振成像的横断面研究，涉及25名年龄在11至18岁之间的ASD青少年和25名年龄、利手和非语言智商相匹配的典型发育青少年。测试全脑功能连接程度和社会功能测量的统计参数图。相对于通常发展中的对照组，ASD参与者在ToM网络中表现出过度连接和连接不足的混合模式，这与更大的社会障碍有关。ASD组中的连接性增加主要在MNS和ToM区域之间检测到，并且与社会交际措施相关，这表明过多的ToM-MNS串扰可能与社会障碍相关。在一项二次分析中，将15名患有ASD的参与者中的一个子集与最严重的神经病学和15名典型发展对照的紧密匹配的子集进行了比较，ASD参与者在ToM和MNS网络中表现出排他性的过度连接效应，这也与更大的社会功能障碍有关。ASD青少年表现出精神化和镜像神经元系统的功能连接性增加，这在很大程度上反映了两者之间更大的串扰。这一发现与ASD中网络隔离减少的新证据一致，并挑战了ASD中一般长距离连接不足的流行理论。这种过度的ToM-MNS连接可能反映了参与理解他人的2个大脑网络中不成熟或异常的发育过程，这是ASD中的一个损伤领域。此外，与ASD的社会交往症状的强大联系暗示了在ASD中观察到的社会缺陷中的ToM-MNS连接的增加。
Converging evidence indicates that brain abnormalities in autism spectrum disorder (ASD) involve atypical network connectivity, but it is unclear whether altered connectivity is especially prominent in brain networks that participate in social cognition. To investigate whether adolescents with ASD show altered functional connectivity in 2 brain networks putatively impaired in ASD and involved in social processing, theory of mind (ToM) and mirror neuron system (MNS). Cross-sectional study using resting-state functional magnetic resonance imaging involving 25 adolescents with ASD between the ages of 11 and 18 years and 25 typically developing adolescents matched for age, handedness, and nonverbal IQ. Statistical parametric maps testing the degree of whole-brain functional connectivity and social functioning measures. Relative to typically developing controls, participants with ASD showed a mixed pattern of both over- and underconnectivity in the ToM network, which was associated with greater social impairment. Increased connectivity in the ASD group was detected primarily between the regions of the MNS and ToM, and was correlated with sociocommunicative measures, suggesting that excessive ToM-MNS cross talk might be associated with social impairment. In a secondary analysis comparing a subset of the 15 participants with ASD with the most severe symptomology and a tightly matched subset of 15 typically developing controls, participants with ASD showed exclusive overconnectivity effects in both ToM and MNS networks, which were also associated with greater social dysfunction. Adolescents with ASD showed atypically increased functional connectivity involving the mentalizing and mirror neuron systems, largely reflecting greater cross talk between the 2. This finding is consistent with emerging evidence of reduced network segregation in ASD and challenges the prevailing theory of general long-distance underconnectivity in ASD. This excess ToM-MNS connectivity may reflect immature or aberrant developmental processes in 2 brain networks involved in understanding of others, a domain of impairment in ASD. Further, robust links with sociocommunicative symptoms of ASD implicate atypically increased ToM-MNS connectivity in social deficits observed in ASD.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
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DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
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DOI：
10.1073/pnas.0811168106
发表时间：
2009-02-10
影响因子：
11.1
作者：
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