Humoral and cellular response to SARS-CoV-2 BNT162b2 mRNA vaccine in hemodialysis patients.
Humoral and cellular response to SARS-CoV-2 BNT162b2 mRNA vaccine in hemodialysis patients.
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DOI：
10.1186/s12865-021-00458-0
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发表时间：
2021-10-19
期刊：
影响因子：
3
通讯作者：
Pauksens K
中科院分区：
文献类型：
--
作者：
Melin J;Svensson MK;Albinsson B;Winqvist O;Pauksens K
血液透析（HD）患者由于许多医疗保健接触而增加了获得感染的风险，此外，可能对疫苗接种反应不佳，并且Covid-19感染的死亡率很高。在50名HD患者（平均年龄69.4岁，62%为男性）中，SARS-CoV-2BNT 162 b2 mRNA疫苗于2020年12月开始接种，并在末次接种后7-15周评估免疫应答。评价了针对核衣壳抗原（抗N）和刺突抗原（抗S）的Covid-19（SARS-CoV-2）IgG抗体水平，以及使用ELISPOT技术针对刺突蛋白的T细胞反应性测试。在50名患者中，在37名（74%）患者中检测到表明疫苗效应或既往Covid-19感染的抗S IgG抗体，5名（10%）患者在接种两剂疫苗后出现临界应答，8名（16%）患者在接种两剂疫苗后呈阴性。29例（58%）检测到T细胞应答。在37例抗S抗体患者中，25例（68%）有可测量的T细胞反应。在5例具有临界抗S抗体的患者中，2例（40%）和2例（25%）无抗S抗体的患者同时出现T细胞应答。27人（54%）同时有抗体和T细胞反应。在7名（14%）患者中检测到抗N IgG抗体，表明既往患有Covid-19疾病。大多数HD患者在接种COVID-19疫苗后会产生B和/或T细胞应答，但约有20%的患者会出现这种应答。20%的患者免疫反应有限。针对Covid-19的T细胞反应性仅存在于少数抗S抗体阴性患者中。
Hemodialysis (HD) patients have an increased risk of acquiring infections due to many health care contacts and may, in addition, have a suboptimal response to vaccination and a high mortality from Covid-19 infection. In 50 HD patients (mean age 69.4 years, 62% men) administration of SARS-CoV-2BNT162b2 mRNA vaccine began in Dec 2020 and the immune response was evaluated 7–15 weeks after the last dose. Levels of Covid-19 (SARS-CoV-2) IgG antibody against the nucleocapsid antigen (anti-N) and the Spike antigen (anti-S) and T-cell reactivity testing against the Spike protein using ELISPOT technology were evaluated. Out of 50 patients, anti-S IgG antibodies indicating a vaccine effect or previous Covid-19 infection, were detected in 37 (74%), 5 (10%) had a borderline response and 8 (16%) were negative after two doses of vaccine. T-cell responses were detected in 29 (58%). Of the 37 patients with anti-S antibodies, 25 (68%) had a measurable T-cell response. 2 (40%) out of 5 patients with borderline anti-S and 2 (25%) without anti-S had a concomitant T-cell response. Twenty-seven (54%) had both an antibody and T-cell response. IgG antibodies to anti-N indicating a previous Covid-19 disease were detected in 7 (14%) patients. Most HD patients develop a B- and/or T-cell response after vaccination against Covid-19 but approx. 20% had a limited immunological response. T-cell reactivity against Covid-19 was only present in a few of the anti-S antibody negative patients.
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DOI：
10.20452/pamw.16028
发表时间：
2021-08-30
影响因子：
4.8
作者：
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DOI：
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发表时间：
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期刊：
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DOI：
10.2215/cjn.03500321
发表时间：
2021-07-01
影响因子：
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Shashar, Moshe
影响因子：
6.1
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Longlune, Nathalie;Nogier, Marie Beatrice;Kamar, Nassim
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影响因子：
19.6
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Espi M;Charmetant X;Barba T;Koppe L;Pelletier C;Kalbacher E;Chalencon E;Mathias V;Ovize A;Cart-Tanneur E;Bouz C;Pellegrina L;Morelon E;Fouque D;Juillard L;Thaunat O
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Thaunat O