Processing speed is correlated with cerebral health markers in the frontal lobes as quantified by neuroimaging.
Processing speed is correlated with cerebral health markers in the frontal lobes as quantified by neuroimaging.
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DOI：
10.1016/j.neuroimage.2009.09.052
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发表时间：
2010-01-15
期刊：
影响因子：
5.7
通讯作者：
Fox, P. T.
中科院分区：
文献类型：
--
作者：
Kochunov, P.;Coyle, T.;Lancaster, J.;Robin, D. A.;Hardies, J.;Kochunov, V.;Bartzokis, G.;Stanley, J.;Royall, D.;Schlosser, A. E.;Null, M.;Fox, P. T.
我们探讨了38名健康成人（年龄57-90岁）认知处理速度（CPS）下降与额叶MRI/MRS脑完整性指数变化之间的关系。CPS评估使用电池的四个定时神经心理学测试：槽钉板，编码，符号数字模式测试，类别流畅性（水果和家具）。对神经心理测验进行因素分析，提取出CPS的两个组成部分：心理健康（PM）和心理物理（PP）。基于MRI的大脑完整性指数包括每个半球的三个皮质测量值：GM厚度、脑回间和脑沟跨度和两个皮质下指数：使用基于轨迹的空间统计（TBSS）测量的各向异性分数（FA）和高信号WM（HWM）体积。MRS指标包括含胆碱化合物（GPC+PC），磷酸肌酸加肌酸（PCr+Cr）和N-乙酰天冬氨酸（NAA），测量双侧额叶WM束的水平。在PM-CPS（58%）的方差的很大一部分是由于萎缩性变化，在额叶WM，观察到的增加，脑沟跨度，FA值的下降和浓度的NAA和含胆碱化合物的减少。PP-CPS中较小比例（20%）的方差可以解释为双侧额沟跨度增加和HWM体积增加。
We explored relationships between decline in cognitive processing speed (CPS) and change in frontal lobe MRI/MRS-based indices of cerebral integrity in 38 healthy adults (age 57–90 years). CPS was assessed using a battery of four timed neuropsychological tests: Grooved Pegboard, Coding, Symbol Digit Modalities Test, and Category Fluency (Fruits and Furniture). The neuropsychological tests were factor analyzed to extract two components of CPS: psychomotor (PM) and psychophysical (PP). MRI-based indices of cerebral integrity included three cortical measurements per hemisphere: GM thickness, intergyral and sulcal spans and two subcortical indices: fractional anisotropy (FA), measured using track-based-spatial-statistics (TBSS), and the volume of hyperintense WM (HWM). MRS indices included levels of choline-containing compounds (GPC+PC), phosphocreatine plus creatine (PCr+Cr), and N-acetylaspartate (NAA), measured bilaterally in the frontal WM bundles. A substantial fraction of the variance in the PM-CPS (58%) was attributed to atrophic changes in frontal WM, observed as increases in sulcal span, declines in FA values and reductions in concentrations of NAA and choline-containing compounds. A smaller proportion (20%) of variance in the PP-CPS could be explained by bilateral increases in frontal sulcal span and increases in HWM volumes.
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影响因子：
4.2
作者：
Bartzokis, George;Lu, Po H.;Tingus, Kathleen;Mendez, Mario F.;Richard, Aurore;Peters, Douglas G.;Oluwadara, Bolanle;Barrall, Katherine A.;Finn, J. Paul;Villablanca, Pablo;Thompson, Paul M.;Mintz, Jim
通讯作者：
Mintz, Jim
影响因子：
11.2
作者：
BRUHN, H;FRAHM, J;BAUER, HJ
通讯作者：
BAUER, HJ
影响因子：
11
作者：
de Leeuw, FE;Barkhof, F;Scheltens, P
通讯作者：
Scheltens, P
影响因子：
4.2
作者：
Abe, O;Aoki, S;Ohtomo, K
通讯作者：
Ohtomo, K
影响因子：
8.3
作者：
GIDEON, P;HENRIKSEN, O;ARLIENSOBORG, P
通讯作者：
ARLIENSOBORG, P