Lifespan trajectory of myelin integrity and maximum motor speed.
Lifespan trajectory of myelin integrity and maximum motor speed.
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DOI：
10.1016/j.neurobiolaging.2008.08.015
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发表时间：
2010-09
影响因子：
4.2
通讯作者：
Mintz, Jim
中科院分区：
文献类型：
--
作者：
Bartzokis, George;Lu, Po H.;Tingus, Kathleen;Mendez, Mario F.;Richard, Aurore;Peters, Douglas G.;Oluwadara, Bolanle;Barrall, Katherine A.;Finn, J. Paul;Villablanca, Pablo;Thompson, Paul M.;Mintz, Jim
关键词：
人类大脑的髓鞘形成导致髓鞘含量和完整性的大致二次轨迹，在中年达到最大值，然后在老年时下降。这种轨迹在脆弱的后期髓鞘形成相关区域（如额叶）中最为明显，可能是认知处理速度相似轨迹的生物学基础。运动速度，如最大手指敲击速度（FTS），需要高频动作电位（AP）爆发，并与髓鞘完整性相关。我们测试的假设，年龄相关的轨迹FTS与脑髓鞘的完整性。在23至80岁之间的非常健康的男性（N = 72）的样本中测量额叶白色物质（FLwm）的髓鞘完整性（计算的横向弛豫率（R2））的灵敏的体内MRI生物标志物。为了评估特异性，还测量了对比早期髓鞘形成区域（胼胝体压部）的R2。FLwm R2和FTS测量值显著相关（r = 0.45，p <0.0001），但在早期髓鞘形成区域（压部）中没有发现相关性。FLwm R2和FTS都具有显著的二次寿命轨迹，几乎无法区分，并且都在39岁时达到峰值，此后随着加速轨迹而下降。结果表明，在这个非常健康的男性样本中，需要高频AP爆发的最大运动速度可能取决于脑髓鞘的完整性。在某种程度上，由R2评估的FLwm变化有助于与年龄相关的AP爆发频率降低，依赖于AP爆发的其他脑功能也可能受到影响。髓鞘完整性的非侵入性测量以及处理速度的基本测量的测试可以帮助开发和靶向抗衰老治疗以减轻与年龄相关的功能衰退。
Myelination of the human brain results in roughly quadratic trajectories of myelin content and integrity, reaching a maximum in mid-life and then declining in older age. This trajectory is most evident in vulnerable later myelinating association regions such as frontal lobes and may be the biological substrate for similar trajectories of cognitive processing speed. Speed of movement, such as maximal finger tapping speed (FTS), requires high-frequency action potential (AP) bursts and is associated with myelin integrity. We tested the hypothesis that the age-related trajectory of FTS is related to brain myelin integrity. A sensitive in vivo MRI biomarker of myelin integrity (calculated transverse relaxation rates (R2)) of frontal lobe white matter (FLwm) was measured in a sample of very healthy males (N = 72) between 23 and 80 years of age. To assess specificity, R2 of a contrasting early-myelinating region (splenium of the corpus callosum) was also measured. FLwm R2 and FTS measures were significantly correlated (r = .45, p < .0001) with no association noted in the early-myelinating region (splenium). Both FLwm R2 and FTS had significantly quadratic lifespan trajectories that were virtually indistinguishable and both reached a peak at 39 years of age and declined with an accelerating trajectory thereafter. The results suggest that in this very healthy male sample, maximum motor speed requiring high-frequency AP burst may depend on brain myelin integrity. To the extent that the FLwm changes assessed by R2 contribute to an age-related reduction in AP burst frequency, it is possible that other brain functions dependent on AP bursts may also be affected. Non-invasive measures of myelin integrity together with testing of basic measures of processing speed may aid in developing and targeting anti-aging treatments to mitigate age-related functional declines.
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影响因子：
--
作者：
Bartzokis, G;Beckson, M;Mintz, J
通讯作者：
Mintz, J
DOI：
10.1080/02724980443000179
发表时间：
2005-01-01
期刊：
QUARTERLY JOURNAL OF EXPERIMENTAL PSYCHOLOGY SECTION A-HUMAN EXPERIMENTAL PSYCHOLOGY
影响因子：
--
作者：
Hedden, T;Lautenschlager, G;Park, DC
通讯作者：
Park, DC
影响因子：
5.6
作者：
Cohen, JA;Fisher, RS;Sze, G
通讯作者：
Sze, G
健康儿童神经运动发育的皮质相关性
影响因子：
4.7
作者：
Garvey, MA;Ziemann, U;Wassermann, EM
通讯作者：
Wassermann, EM
DOI：
10.1080/01688638308401171
发表时间：
1983-01-01
期刊：
JOURNAL OF CLINICAL NEUROPSYCHOLOGY
影响因子：
--
作者：
FROMMAUCH, D;YEUDALL, LT
通讯作者：
YEUDALL, LT