Cardiovascular effects of electronic cigarettes.
Cardiovascular effects of electronic cigarettes.
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DOI：
10.1038/nrcardio.2017.36
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发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Fraiman JB
中科院分区：
文献类型：
--
作者：
Benowitz NL;Fraiman JB
心血管安全性是关于使用电子烟（EC）的益处与风险的辩论中的一个重要考虑因素。可能对心血管健康产生不利影响的EC排放物包括尼古丁、氧化剂、醛类、颗粒物和香料。迄今为止，在人体中证明的EC的大多数心血管作用与尼古丁的已知作用一致。药理学和毒理学研究支持尼古丁促进急性心血管事件和加速动脉粥样硬化形成的生物学可解释性。然而，评估瑞典无烟烟草的流行病学研究，使使用者暴露于没有燃烧产物的尼古丁，通常没有发现使用者心肌梗死或中风的风险增加，但表明尼古丁可能导致急性心血管事件，特别是在那些有潜在冠心病的人中。来自EC的醛类、颗粒物和香料对心血管健康的影响尚未确定。虽然EC可能会对使用者造成一些心血管风险，特别是那些患有心血管疾病的人，但基于EC气雾剂与香烟烟雾成分的定性和定量比较，认为其风险低于吸烟。因此，采用EC而不是吸烟可能会对公众健康产生整体效益。
Cardiovascular safety is an important consideration in the debate on the benefits versus the risks of electronic cigarette (EC) use. EC emissions that might have adverse effects on cardiovascular health include nicotine, oxidants, aldehydes, particulates, and flavourants. To date, most of the cardiovascular effects of ECs demonstrated in humans are consistent with the known effects of nicotine. Pharmacological and toxicological studies support the biological plausibility that nicotine contributes to acute cardiovascular events and accelerated atherogenesis. However, epidemiological studies assessing Swedish smokeless tobacco, which exposes users to nicotine without combustion products, generally have not found an increased risk of myocardial infarction or stroke among users, but suggest that nicotine might contribute to acute cardiovascular events, especially in those with underlying coronary heart disease. The effects of aldehydes, particulates, and flavourants derived from ECs on cardiovascular health have not been determined. Although ECs might pose some cardiovascular risk to users, particularly those with existing cardiovascular disease, the risk is thought to be less than that of cigarette smoking based on qualitative and quantitative comparisons of EC aerosol versus cigarette smoke constituents. The adoption of ECs rather than cigarette smoking might, therefore, result in an overall benefit for public health.
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影响因子：
37.8
作者：
Bhatnagar A;Whitsel LP;Ribisl KM;Bullen C;Chaloupka F;Piano MR;Robertson RM;McAuley T;Goff D;Benowitz N;American Heart Association Advocacy Coordinating Committee, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and Council on Quality of Care and Outcomes Research
通讯作者：
American Heart Association Advocacy Coordinating Committee, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and Council on Quality of Care and Outcomes Research
影响因子：
3.7
作者：
Caponnetto P;Campagna D;Cibella F;Morjaria JB;Caruso M;Russo C;Polosa R
通讯作者：
Polosa R
影响因子：
168.9
作者：
Bullen, Christopher;Howe, Colin;Walker, Natalie
通讯作者：
Walker, Natalie
影响因子：
5.3
作者：
Antoniewicz, Lukasz;Bosson, Jenny A.;Lundback, Magnus
通讯作者：
Lundback, Magnus
影响因子：
6
作者：
Brown, Jamie;Beard, Emma;West, Robert
通讯作者：
West, Robert