Regulation of human salt-sensitivite hypertension by myeloid cell renin-angiotensin-aldosterone system.
Regulation of human salt-sensitivite hypertension by myeloid cell renin-angiotensin-aldosterone system.
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髓系细胞肾素-血管紧张素-醛固酮系统对盐敏感性高血压的调节作用。
DOI：
10.3389/fphys.2023.1208270
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发表时间：
2023
影响因子：
4
通讯作者：
Kirabo, Annet
中科院分区：
文献类型：
--
作者：
Ertuglu, Lale A. A.;Mutchler, Ashley Pitzer;Elijovich, Fernando;Laffer, Cheryl L. L.;Sheng, Quanhu;Wanjalla, Celestine N. N.;Kirabo, Annet
Introduction: Salt sensitivity of blood pressure is a phenomenon in which blood pressure changes according to dietary sodium intake. Our previous studies found that high salt activates antigen presenting cells, resulting in the development of hypertension. The mechanisms by which salt-induced immune cell activation is regulated in salt sensitivity of blood pressure are unknown. In the current study, we investigated dietary salt-induced effects on the renin-angiotensin-aldosterone system (RAAS) gene expression in myeloid immune cells and their impact on salt sensitive hypertension in humans. Methods: We performed both bulk and single-cell sequencing analysis on immune cells with in vitro and in vivo high dietary salt treatment in humans using a rigorous salt-loading/depletion protocol to phenotype salt-sensitivity of blood pressure. We also measured plasma renin and aldosterone using radioimmunoassay. Results: We found that while in vitro high sodium exposure downregulated the expression of renin, renin binding protein and renin receptor, there were no significant changes in the genes of the renin-angiotensin system in response to dietary salt loading and depletion in vivo. Plasma renin in salt sensitive individuals tended to be lower with a blunted response to the salt loading/depletion challenge as previously reported. Discussion: These findings suggest that unlike systemic RAAS, acute changes in dietary salt intake do not regulate RAAS expression in myeloid immune cells.
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影响因子：
10.8
作者：
Ruggeri Barbaro N;Van Beusecum J;Xiao L;do Carmo L;Pitzer A;Loperena R;Foss JD;Elijovich F;Laffer CL;Montaniel KR;Galindo CL;Chen W;Ao M;Mernaugh RL;Alsouqi A;Ikizler TA;Fogo AB;Moreno H;Zhao S;Davies SS;Harrison DG;Kirabo A
通讯作者：
Kirabo A
影响因子：
20.1
作者：
Pitzer, Ashley;Elijovich, Fernando;Laffer, Cheryl L.;Ertuglu, Lale A.;Sahinoz, Melis;Saleem, Mohammad;Krishnan, Jaya;Dola, Thanvi;Aden, Luul A.;Sheng, Quanhu;Raddatz, Michael A.;Wanjalla, Celestine;Pakala, Suman;Davies, Sean S.;Patrick, David M.;Kon, Valentina;Ikizler, T. Alp;Kleyman, Thomas;Kirabo, Annet
通讯作者：
Kirabo, Annet
影响因子：
3.7
作者：
Song, Xiang;Hu, Wei;Zhao, Yong
通讯作者：
Zhao, Yong
影响因子：
8.3
作者：
He, FJ;Markandu, ND;MacGregor, GA
通讯作者：
MacGregor, GA
影响因子：
20.3
作者：
Geisberger, Sabrina;Maschke, Ulrike;Binger, Katrina J.
通讯作者：
Binger, Katrina J.