Experimental mouse models for translational human cancer research.
Experimental mouse models for translational human cancer research.
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DOI：
10.3389/fimmu.2023.1095388
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发表时间：
2023
影响因子：
7.3
通讯作者：
Lei, Jie
中科院分区：
文献类型：
--
作者：
Zhou, Yinxi;Xia, Jinghua;Xu, Shuonan;She, Tao;Zhang, Yanning;Sun, Ying;Wen, Miaomiao;Jiang, Tao;Xiong, Yanlu;Lei, Jie
肿瘤的发展和生长仍然是世界各地人类生命的重要和持续威胁。虽然免疫检查点疗法和CAR-T等先进的治疗策略在实体瘤和血液恶性肿瘤的治疗方面取得了惊人的进展，但癌症的恶性起始和进展仍然是一个有争议的问题，迫切需要进一步研究。实验动物模型不仅在模拟肿瘤的发生、发展和恶变机制方面具有巨大优势，而且可用于评价多种临床干预措施的治疗效果，逐渐成为肿瘤研究不可或缺的手段。本文就自发性、诱导性、转基因和可移植性肿瘤模型的研究进展进行综述，以期对今后肿瘤发生机制和预防的研究有所指导。
The development and growth of tumors remains an important and ongoing threat to human life around the world. While advanced therapeutic strategies such as immune checkpoint therapy and CAR-T have achieved astonishing progress in the treatment of both solid and hematological malignancies, the malignant initiation and progression of cancer remains a controversial issue, and further research is urgently required. The experimental animal model not only has great advantages in simulating the occurrence, development, and malignant transformation mechanisms of tumors, but also can be used to evaluate the therapeutic effects of a diverse array of clinical interventions, gradually becoming an indispensable method for cancer research. In this paper, we have reviewed recent research progress in relation to mouse and rat models, focusing on spontaneous, induced, transgenic, and transplantable tumor models, to help guide the future study of malignant mechanisms and tumor prevention.
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影响因子：
64.8
作者：
DONEHOWER, LA;HARVEY, M;BRADLEY, A
通讯作者：
BRADLEY, A
影响因子：
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作者：
Bade, Brett C.;Dela Cruz, Charles S.
通讯作者：
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4.6
作者：
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通讯作者：
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作者：
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RICE, JM
影响因子：
56.9
作者：
Di Cristofano, A;Kotsi, P;Pandolfi, PP
通讯作者：
Pandolfi, PP