Resveratrol protects against experimental stroke: putative neuroprotective role of heme oxygenase 1.
Resveratrol protects against experimental stroke: putative neuroprotective role of heme oxygenase 1.
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DOI：
10.1016/j.expneurol.2010.03.032
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发表时间：
2010-07
影响因子：
5.3
通讯作者：
Dore, Sylvain
中科院分区：
文献类型：
--
作者：
Sakata, Yoshihito;Zhuang, Hean;Kwansa, Herman;Koehler, Raymond C.;Dore, Sylvain
流行病学和实验报告表明，轻度至中度饮用葡萄酒和/或葡萄可降低心血管、脑血管和外周血管风险的发生率。这项研究表明，白藜芦醇是红酒中富含的生物活性多酚，它可以在培养的小鼠皮质神经元细胞中以剂量和时间依赖性方式选择性诱导血红素加氧酶 1 (HO1)，并提供神经保护，使其免受自由基或兴奋性毒性损伤。当细胞用蛋白质合成或血红素加氧酶抑制剂处理时，这种保护作用就会消失，这表明白藜芦醇的预防特性至少部分需要 HO1 诱导。此外，白藜芦醇预处理剂量依赖性地保护接受优化的缺血再灌注中风模型的小鼠。 HO1被选择性删除的小鼠失去了大部分（如果不是全部的话）有益效果。总之，这些数据表明了一种潜在的细胞内途径，白藜芦醇可以通过该途径提供细胞/器官对神经病理状况的抵抗力。
Epidemiological and experimental reports have linked mild-to-moderate wine and/or grape consumption to a lowered incidence of cardiovascular, cerebrovascular, and peripheral vascular risk. This study revealed that resveratrol, an enriched bioactive polyphenol in red wine, selectively induces heme oxygenase 1 (HO1) in a dose- and time-dependent manner in cultured mouse cortical neuronal cells and provides neuroprotection from free-radical or excitotoxicity damage. This protection was lost when cells were treated with a protein synthesis or heme oxygenase inhibitor, suggesting that HO1 induction is at least partially required for resveratrol’s prophylactic properties. Furthermore, resveratrol pretreatment dose-dependently protected mice subjected to an optimized ischemic-reperfusion stroke model. Mice in which HO1 was selectively deleted lost most, if not all, of the beneficial effects. Together, the data suggest a potential intracellular pathway by which resveratrol can provide cell/organ resistance against neuropathological conditions.
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影响因子：
4.2
作者：
Saleem, Sofiyan;Li, Rung-Chi;Dore, Sylvain
通讯作者：
Dore, Sylvain
影响因子：
5.7
作者：
Doré, S;Sampei, K;Snyder, SH
通讯作者：
Snyder, SH
影响因子：
3.7
作者：
Barger JL;Kayo T;Vann JM;Arias EB;Wang J;Hacker TA;Wang Y;Raederstorff D;Morrow JD;Leeuwenburgh C;Allison DB;Saupe KW;Cartee GD;Weindruch R;Prolla TA
通讯作者：
Prolla TA
影响因子：
3
作者：
de Lorimier, AA
通讯作者：
de Lorimier, AA
DOI：
10.2174/187153008784534385
发表时间：
2008-06-01
影响因子：
1.9
作者：
Liu, Ling;Wang, Yu;Xu, Aimin
通讯作者：
Xu, Aimin