A novel three serum phospholipid panel differentiates normal individuals from those with prostate cancer.
A novel three serum phospholipid panel differentiates normal individuals from those with prostate cancer.
复制标题
DOI：
10.1371/journal.pone.0088841
复制
发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Kelavkar U
中科院分区：
文献类型：
--
作者：
Patel N;Vogel R;Chandra-Kuntal K;Glasgow W;Kelavkar U
前列腺特异性抗原（PSA）和直肠指检（DRE）筛查的结果导致前列腺癌（PCa）治疗不足和过度。因此，迫切需要鉴定和评估用于早期诊断和疾病预后的新标志物。研究表明PCa、脂质和脂质代谢之间存在联系。因此，本研究的目的是检查与对照组血清相比，前列腺癌患者的血清脂质的浓度和分布。使用电喷雾电离质谱（ESI-MS/MS）脂质分析，我们分析了来自年龄匹配的受试者的血清磷脂，这些受试者是新诊断的PCa或健康（正常）。我们发现胆固醇（CE）、二氢鞘磷脂（DSM）、磷脂酰胆碱（PC）、卵磷脂酰胆碱（ePC）和卵磷脂酰乙醇胺（ePE）是正常人和癌症患者血清中存在差异的5种主要脂类。与正常血清相比，ePC 38：5、PC 40：3和PC 42：4代表PCa中最常见的脂质种类。进一步分析显示，血清ePC 38：5 ≥ 0.015 nmoles、PC 40.3 ≤ 0.001 nmoles和PC 42：4 ≤ 0.0001 nmoles与94%预测值下不存在PCa相关。相反，血清ePC 38：5 ≤ 0.015 nmoles、PC 40：3 ≥ 0.001 nmoles和PC 42：4 ≥ 0.0001 nmoles与PCa的存在相关。总之，我们已经证明ePC 38：5、PC 40：3和PC 42：4可以作为PCa存在的早期预测血清标志物。
The results of prostate specific antigen (PSA) and digital rectal examination (DRE) screenings lead to both under and over treatment of prostate cancer (PCa). As such, there is an urgent need for the identification and evaluation of new markers for early diagnosis and disease prognosis. Studies have shown a link between PCa, lipids and lipid metabolism. Therefore, the aim of this study was to examine the concentrations and distribution of serum lipids in patients with PCa as compared with serum from controls. Using Electrospray ionization mass spectrometry (ESI-MS/MS) lipid profiling, we analyzed serum phospholipids from age-matched subjects who were either newly diagnosed with PCa or healthy (normal). We found that cholester (CE), dihydrosphingomyelin (DSM), phosphatidylcholine (PC), egg phosphatidylcholine (ePC) and egg phoshphatidylethanolamine (ePE) are the 5 major lipid groups that varied between normal and cancer serums. ePC 38:5, PC 40:3, and PC 42:4 represent the lipids species most prevalent in PCa as compared with normal serum. Further analysis revealed that serum ePC 38:5 ≥0.015 nmoles, PC 40.3 ≤0.001 nmoles and PC 42:4 ≤0.0001 nmoles correlated with the absence of PCa at 94% prediction. Conversely, serum ePC 38:5 ≤0.015 nmoles, PC 40:3 ≥0.001 nmoles, and PC 42:4 ≥0.0001 nmoles correlated with the presence of PCa. In summary, we have demonstrated that ePC 38:5, PC 40:3, and PC 42:4 may serve as early predictive serum markers for the presence of PCa.
登录
查看更多内容
影响因子：
168.9
作者：
Grönberg, H
通讯作者：
Grönberg, H
DOI：
10.1097/01.ju.0000142068.66876.53
发表时间：
2004-11-01
期刊：
The Journal of urology
影响因子：
--
作者：
Chan, June M;Jou, Ronald M;Carroll, Peter R
通讯作者：
Carroll, Peter R
影响因子：
3.8
作者：
Devaiah, Shivakumar Pattada;Roth, Mary R.;Wang, Xuemin
通讯作者：
Wang, Xuemin
影响因子：
3
作者：
Kim, SY;Volsky, DJ
通讯作者：
Volsky, DJ
影响因子：
5
作者：
Epstein, Mara M.;Kasperzyk, Julie L.;Andren, Ove
通讯作者：
Andren, Ove