Maternal ethnicity and the prevalence of British pregnancies affected by neural tube defects.
Maternal ethnicity and the prevalence of British pregnancies affected by neural tube defects.
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DOI：
10.1002/bdr2.1893
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发表时间：
2021-07-15
影响因子：
2.1
通讯作者：
Copp AJ
中科院分区：
文献类型：
--
作者：
Peake JN;Knowles RL;Shawe J;Rankin J;Copp AJ
关于英国不同种族社区内神经管缺陷（NTDs）的患病率的数据很少。本研究的目的是计算患病率估计NTD影响的怀孕，按母亲的种族分类，并探讨为什么患病率的变化可能存在。对2006年至2011年期间英格兰和威尔士地区先天性异常登记处的NTD影响妊娠的数据进行了横断面研究。使用二项回归模型，我们研究了NTD影响的妊娠患病率估计和率比（PRR），母亲的种族。NTD的患病率为每10，000名新生儿12.14例，研究年份之间没有差异。无脑儿、脑膨出和脊柱裂的发生率分别为4.98/万、1.37/万和5.80/万。在调整了产妇剥夺和产妇年龄后，印度裔母亲和孟加拉裔母亲患NTD的可能性分别是白色母亲的1.84倍（95% CI：1.24，2.73）和2.86倍（95% CI：1.48，5.53）。印度母亲的过度患病率特别是无脑畸形（PRR 2.57; 95% CI：1.52，4.34），孟加拉国母亲的趋势是脊柱裂增加（PRR 3.86; 95% CI：0.72，8.69）。印度母亲的无脑畸形尤其与其他先天性异常（非孤立性NTD）相关。不同的英国族群NTD患病率不同。无脑畸形作为一种非孤立的NTD在印度母亲怀孕的过度患病率可能表明参与遗传或其他不可测量的行为因素。未来的工作需要寻求病因学解释种族差异，并制定改进的一级预防方法。
Few data are available on the prevalence of neural tube defects (NTDs) within different ethnic communities of the UK. This study aimed to calculate prevalence estimates for NTD-affected pregnancies, classified by maternal ethnicity, and to explore why variations in prevalence might exist. A cross-sectional study was performed with data from regional congenital anomaly registers in England and Wales, for NTD-affected pregnancies between 2006 and 2011. Using binomial regression models, we examined NTD-affected pregnancy prevalence estimates and rate ratios (PRRs), by maternal ethnicity. The prevalence of NTDs was 12.14 per 10,000 births, with no differences between study years. Anencephaly, encephalocele and spina bifida occurred at 4.98, 1.37 and 5.80 per 10,000 births respectively. Mothers of Indian ethnicity were 1.84 times more likely (95% CI: 1.24, 2.73) and Bangladeshi mothers 2.86 times more likely (95% CI: 1.48, 5.53) than White mothers to have an NTD-affected pregnancy, after adjusting for maternal deprivation and maternal age. The excess prevalence in Indian mothers was specifically for anencephaly (PRR 2.57; 95% CI: 1.52, 4.34), and in Bangladeshi mothers the trend was for increased spina bifida (PRR 3.86; 95% CI: 0.72, 8.69). Anencephaly in Indian mothers was especially associated with other congenital anomalies (non-isolated NTDs). Different British ethnic groups vary in NTD prevalence. The excess prevalence of anencephaly as a non-isolated NTD in pregnancies of Indian mothers could indicate involvement of genetic or other unmeasured behavioral factors. Future work is needed to seek etiological explanations for the ethnicity differences and to develop improved methods for primary prevention.
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影响因子：
3.7
作者：
Allagh KP;Shamanna BR;Murthy GV;Ness AR;Doyle P;Neogi SB;Pant HB;Wellcome Trust- PHFI Folic Acid project team
通讯作者：
Wellcome Trust- PHFI Folic Acid project team
影响因子：
158.5
作者：
CZEIZEL, AE;DUDAS, I
通讯作者：
DUDAS, I
影响因子：
2.5
作者：
Bittles, A. H.;Black, M. L.
通讯作者：
Black, M. L.
DOI：
10.1016/0140-6736(91)90133-a
发表时间：
1991-07-20
期刊：
Lancet (London, England)
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1002/ajmg.c.30057
发表时间：
2005-05-15
影响因子：
3.1
作者：
Mitchell, LE
通讯作者：
Mitchell, LE