Birth prevalence of neural tube defects and orofacial clefts in India: a systematic review and meta-analysis.
Birth prevalence of neural tube defects and orofacial clefts in India: a systematic review and meta-analysis.
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DOI：
10.1371/journal.pone.0118961
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Wellcome Trust- PHFI Folic Acid project team
中科院分区：
文献类型：
--
作者：
Allagh KP;Shamanna BR;Murthy GV;Ness AR;Doyle P;Neogi SB;Pant HB;Wellcome Trust- PHFI Folic Acid project team
在过去二十年中，印度因传染病和营养不良造成的婴儿死亡率大幅下降。然而，出生缺陷导致的死亡率保持不变。在印度，关于神经管缺陷和口面裂等出生缺陷患病率的研究报告了不一致的结果。因此，我们对观察性研究进行了系统回顾，以记录神经管缺陷和口面裂的出生患病率。在MEDLINE和EMBASE数据库中对观察性研究进行了全面的文献检索，使用关键MeSH术语（神经管缺陷或唇裂或腭裂以及患病率和印度）。两名审稿人独立审查了检索到的研究，并纳入了符合资格的研究。采用STROBE声明中选定的标准评估纳入研究的质量。印度神经管缺陷的总体合并出生患病率（随机效应）为每1000个新生儿中有4.5个（95%可信区间4.2至4.9）。唇腭裂的总体合并出生患病率（随机效应）为每1000个新生儿中有1.3个（95%可信区间1.1至1.5）。按地区、时间、血缘、性别进行亚组分析。与世界其他地区相比，印度神经管缺陷的总体患病率较高，而口面裂的患病率与其他国家相似。该综述中纳入的大多数研究都是基于医院的。这些研究的质量从低到中等不等。需要进一步精心设计、高质量的社区观察性研究，以准确估计印度神经管缺损和口面裂的负担。
In the last two decades, India has witnessed a substantial decrease in infant mortality attributed to infectious disease and malnutrition. However, the mortality attributed to birth defects remains constant. Studies on the prevalence of birth defects such as neural tube defects and orofacial clefts in India have reported inconsistent results. Therefore, we conducted a systematic review of observational studies to document the birth prevalence of neural tube defects and orofacial clefts. A comprehensive literature search for observational studies was conducted in MEDLINE and EMBASE databases using key MeSH terms (neural tube defects OR cleft lip OR cleft palate AND Prevalence AND India). Two reviewers independently reviewed the retrieved studies, and studies satisfying the eligibility were included. The quality of included studies was assessed using selected criteria from STROBE statement. The overall pooled birth prevalence (random effect) of neural tube defects in India is 4.5 per 1000 total births (95% CI 4.2 to 4.9). The overall pooled birth prevalence (random effect) of orofacial clefts is 1.3 per 1000 total births (95% CI 1.1 to 1.5). Subgroup analyses were performed by region, time period, consanguinity, and gender of newborn. The overall prevalence of neural tube defects from India is high compared to other regions of the world, while that of orofacial clefts is similar to other countries. The majority of studies included in the review were hospital based. The quality of these studies ranged from low to moderate. Further well-designed, high quality community-based observational studies are needed to accurately estimate the burden of neural tube defects and orofacial clefts in India.
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影响因子：
1.9
作者：
Jaikrishan, G.;Sudheer, K. R.;Seshadri, M.
通讯作者：
Seshadri, M.
影响因子：
4.3
作者：
Bhat, B. Vishnu;Babu, Lokesh
通讯作者：
Babu, Lokesh
影响因子：
4.3
作者：
CHOUDHURY A R;MUKHERJEE M;GHOSH P K
通讯作者：
GHOSH P K
DOI：
10.4103/0970-0358.57182
发表时间：
2009-10
期刊：
Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India
影响因子：
--
作者：
Mossey P;Little J
通讯作者：
Little J
影响因子：
2.1
作者：
Gupta, Supriya;Arora, Sarika;Singh, Ritu
通讯作者：
Singh, Ritu