Blood-retinal barrier breakdown in experimental coronavirus retinopathy: association with viral antigen, inflammation, and VEGF in sensitive and resistant strains.
Blood-retinal barrier breakdown in experimental coronavirus retinopathy: association with viral antigen, inflammation, and VEGF in sensitive and resistant strains.
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DOI：
10.1016/s0165-5728(01)00374-5
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发表时间：
2001-10-01
影响因子：
3.3
通讯作者：
Hooks JJ
中科院分区：
文献类型：
--
作者：
Vinores SA;Wang Y;Vinores MA;Derevjanik NL;Shi A;Klein DA;Detrick B;Hooks JJ
眼内冠状病毒接种导致易感小鼠（BALB/c）的双相视网膜疾病，其特征在于急性炎症反应，随后是与自身免疫反应性相关的视网膜变性。抗性小鼠（CD-1），当同样接种时，只发展疾病的早期阶段。血视网膜屏障（BRB）的破坏发生在两种菌株的早期阶段，与炎症的发作一致。随着炎症消退，视网膜血管渗漏的程度降低，表明实验性冠状病毒视网膜病变（ECOR）中的BRB分解主要是由于炎症而不是视网膜细胞破坏。血管内皮生长因子（VEGF）仅在继发性（视网膜变性）阶段的易感小鼠中上调。
Intraocular coronavirus inoculation results in a biphasic retinal disease in susceptible mice (BALB/c) characterized by an acute inflammatory response, followed by retinal degeneration associated with autoimmune reactivity. Resistant mice (CD-1), when similarly inoculated, only develop the early phase of the disease. Blood–retinal barrier (BRB) breakdown occurs in the early phase in both strains, coincident with the onset of inflammation. As the inflammation subsides, the extent of retinal vascular leakage is decreased, indicating that BRB breakdown in experimental coronavirus retinopathy (ECOR) is primarily due to inflammation rather than to retinal cell destruction. Vascular endothelial growth factor (VEGF) is upregulated only in susceptible mice during the secondary (retinal degeneration) phase.
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