Effects of a liquid high-fat meal on postprandial lipid metabolism in type 2 diabetic patients with abdominal obesity.
Effects of a liquid high-fat meal on postprandial lipid metabolism in type 2 diabetic patients with abdominal obesity.
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流质高脂膳食对腹型肥胖2型糖尿病患者餐后脂代谢的影响
DOI：
10.1186/s12986-017-0211-5
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发表时间：
2017
影响因子：
4.5
通讯作者：
Sun G
中科院分区：
文献类型：
--
作者：
Wang F;Lu H;Liu F;Cai H;Song Z;Guo F;Xie Y;Shu G;Sun G
研究背景餐后血脂和脂蛋白脂酶(LPL)活性在动脉粥样硬化的发病机制中起着重要作用。方法对51例2型糖尿病腹型肥胖症患者、31例非腹型肥胖型2型糖尿病患者空腹及餐后0.5、1、2、4、6、8h的血糖、胰岛素、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDLc)进行检测。结果2型糖尿病腹型肥胖组餐后血糖曲线下面积[最小二乘均方差=30.763，95%可信区间=23.071~38.455，F=0.37.346，P<0.05]和总胆固醇[最小均方差=0.3.995，95%可信区间=1.043~6.947，P<；0.05]显著高于对照组。餐后胰岛素、稳态模型评估-胰岛素抵抗(HOMA-IR)和甘油三酯(TG)的AUC较高(LSMD=37.421-136.553，F=37.421-136.553，F=16.739，P<；00.05；LSMD=37.456，95%CI=16.312-58.600，F=27.012，P<；00.05；LSMD=44.684，95%CI=2.662-6.705，F=0.26.158，P<；而有腹型肥胖者高密度脂蛋白胆固醇AUC低于非腹型肥胖者(−=1.652，95%CI=−2.685~0.620，F=8.190，P<0.05)。在2型糖尿病腹型肥胖患者中，P−/−患者餐后TG AUC低于P+/−表型(−=4.393，95%CI=−9.278--0.491，F=0.4.476，P<0.0 5)和P+/+表型(−=7.180，95%CI=−12.319--2.014，F=0.4.476，P&t；0.05)。根据PvuII表型，餐后血糖、胰岛素、HOMA-IR、总胆固醇和高密度脂蛋白胆固醇的AUC无差异。结论肥胖加重了2型糖尿病患者的餐后血脂反应，这在一定程度上解释了2型糖尿病患者动脉粥样硬化的风险。此外，P+等位基因的存在可能导致伴有腹部肥胖的2型糖尿病患者餐后甘油三酯增加更大。试验登记：ChiCTR-IOR-16008435。已于2016年5月8日注册。
BackgroundPostprandial lipemia and lipoprotein lipase (LPL) activity play crucial roles in the pathogenesis of accelerated atherosclerosis. This study aimed to evaluate the postprandial lipid metabolism after the ingestion of a liquid high-fat meal in type 2 diabetic patients with abdominal obesity, and determine if the PvuII polymorphisms of LPL influence their postprandial lipid responses.MethodsSerum glucose, insulin, triglycerides (TG), total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) were measured in fasting and postprandial state at 0.5, 1, 2, 4, 6 and 8 h after a liquid high-fat meal in 51 type 2 diabetic patients with abdominal obesity, 31 type 2 diabetic patients without abdominal obesity and 39 controls. Their PvuII polymorphisms of LPL were tested in fasting.ResultsType 2 diabetic patients with abdominal obesity had significantly higher postprandial areas under the curve (AUC) of glucose [least square mean difference (LSMD) = 30.763, 95% confidence interval (CI) = 23.071–38.455,F= 37.346,P< 0.05] and TC (LSMD = 3.995, 95% CI = 1.043–6.947,F= 3.681,P< 0.05) than controls. Postprandial AUCs for insulin, homeostasis model assessment-insulin resistance (HOMA-IR) and TG were higher (LSMD = 86.987, 95% CI = 37.421–136.553,F= 16.739,P< 0.05; LSMD = 37.456, 95% CI = 16.312–58.600,F= 27.012,P< 0.05; LSMD = 4.684, 95% CI = 2.662–6.705,F= 26.158,P< 0.05), whereas HDL-C AUC was lower (LSMD = −1.652, 95% CI = −2.685 – -0.620,F= 8.190,P< 0.05) in type 2 diabetic subjects with abdominal obesity than those without abdominal obesity. In type 2 diabetic patients with abdominal obesity, postprandial TG AUC was lower in P−/− than in P+/− (LSMD = −4.393, 95% CI = −9.278 – -0.491,F= 4.476,P< 0.05) and P+/+ (LSMD = −7.180, 95% CI = −12.319 – -2.014,F= 4.476,P< 0.05) phenotypes. Postprandial AUCs for glucose, insulin, HOMA-IR, TC and HDL-C were not different according to PvuII phenotypes.ConclusionsAbdominal obesity exacerbates the postprandial lipid responses in type 2 diabetic patients, which partly explains the excess atherogenic risk in these patients. In addition, the presence of P+ allele could contribute to a greater postprandial TG increase in type 2 diabetic patients with abdominal obesity.Trial registrationChiCTR-IOR- 16008435 . Registered 8 May 2016.
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影响因子：
5.9
作者：
Al-Disi DA;Al-Daghri NM;Khan N;Alfadda AA;Sallam RM;Alsaif M;Sabico S;Tripathi G;McTernan PG
通讯作者：
McTernan PG
影响因子：
39.2
作者：
Axelsen, M;Smith, U;Jansson, PA
通讯作者：
Jansson, PA
DOI：
10.2165/00129784-200404040-00004
发表时间：
2004-01-01
期刊：
American journal of cardiovascular drugs : drugs, devices, and other interventions
影响因子：
--
作者：
Chan, Dick C;Barrett, Hugh P R;Watts, Gerald F
通讯作者：
Watts, Gerald F
DOI：
10.1152/ajpendo.2001.281.3.e626
发表时间：
2001-09-01
影响因子：
5.1
作者：
Mamo, JCL;Watts, GF;Pal, S
通讯作者：
Pal, S
影响因子：
3.5
作者：
Shin, Eunjung;Park, Na-Young;Lee, Myoungsook
通讯作者：
Lee, Myoungsook