Phospholipase C-mediated hydrolysis of phosphatidylcholine is a target of transforming growth factor beta 1 inhibitory signals
Phospholipase C-mediated hydrolysis of phosphatidylcholine is a target of transforming growth factor beta 1 inhibitory signals
复制标题
磷脂酶 C 介导的磷脂酰胆碱水解是转化生长因子 β 1 抑制信号的目标
DOI：
--
复制
发表时间：
1992
影响因子：
5.3
通讯作者：
J. Moscat
中科院分区：
文献类型：
--
作者：
M. Diaz;I. Dominguez;L. Sanz;M. M. Municio;E. Berra;M. E. Cornet;A. García de Herreros;T. Johansen;J. Moscat
Cell growth and tumor transformation can be restrained in certain cell systems by the action of transforming growth factor beta (TGF-beta). It has been established that the mechanism whereby TGF-beta 1 inhibits cell growth does not interfere with the triggering of early mitogenic signal transduction mechanisms. Phospholipase C-catalyzed hydrolysis of phosphatidylcholine (PC) is a relatively late step in the cascade activated by growth factors. Therefore, conceivably activation of phospholipase C-catalyzed hydrolysis of PC could be the target of TGF-beta 1 action. In the study reported here, we demonstrate that TGF-beta 1 inhibits the coupling of ras p21 to the activation of PC hydrolysis, which appears to be critical for the antiproliferative effects of TGF-beta 1.
登录
查看更多内容
影响因子：
56.9
作者：
DOOLITTLE, RF;HUNKAPILLER, MW;ANTONIADES, HN
通讯作者：
ANTONIADES, HN
影响因子：
16.6
作者：
M. Barbacid
通讯作者：
M. Barbacid
β型转化生长因子的抗增殖作用发生在远离生长激活因子受体的水平。
DOI：
--
发表时间：
1986
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Like,B;Massagué,J
通讯作者：
Massagué,J
影响因子：
--
作者：
Bill CA;Vines CM
通讯作者：
Vines CM