The mucosal immune system of fish: the evolution of tolerating commensals while fighting pathogens.
The mucosal immune system of fish: the evolution of tolerating commensals while fighting pathogens.
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鱼类的粘膜免疫系统：耐受共生体同时对抗病原体的进化。
DOI：
10.1016/j.fsi.2013.09.032
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发表时间：
2013-12
影响因子：
4.7
通讯作者：
Salinas, Irene
中科院分区：
文献类型：
--
作者：
Gomez, Daniela;Sunyer, J. Oriol;Salinas, Irene
在过去的几年里，粘膜免疫学的研究领域发展迅速，我们对粘膜表面如何对复杂的抗原鸡尾酒做出反应的了解正在极大地扩展。随着新的分子测序技术的出现，人们更容易理解脊椎动物的免疫系统在很大程度上是如何由与宿主共生的复杂微生物群落协调的。这种共生微生物区系现在被许多科学家视为“延伸自我”。同样，鱼类免疫学家也在粘膜免疫和共生方面投入了重要的研究努力。最近，我们对硬骨鱼粘膜免疫反应的了解取得了突破，为硬骨鱼作为研究人类粘膜疾病的动物模型打开了潜力。此外，这一新知识使免疫学家在合理设计粘膜疫苗和其他免疫疗法的同时，能够更好地针对鱼类粘膜免疫系统。本文综述了硬骨鱼皮肤、鳃和肠道免疫细胞和分子如何对病原体和共生体作出反应的最新观点。最后，强调了鱼类粘膜免疫领域在未来几年可能遵循的一些未来途径。
The field of mucosal immunology research has grown fast over the past few years, and our understanding on how mucosal surfaces respond to complex antigenic cocktails is expanding tremendously. With the advent of new molecular sequencing techniques, it is easier to understand how the immune system of vertebrates is, to a great extent, orchestrated by the complex microbial communities that live in symbiosis with their hosts. The commensal microbiota is now seen as the “extended self” by many scientists. Similarly, fish immunologist are devoting important research efforts to the field of mucosal immunity and commensals. Recent breakthroughs on our understanding of mucosal immune responses in teleost fish open up the potential of teleosts as animal research models for the study of human mucosal diseases. Additionally, this new knowledge places immunologists in a better position to specifically target the fish mucosal immune system while rationally designing mucosal vaccines and other immunotherapies. In this review, an updated view on how teleost skin, gills and gut immune cells and molecules, function in response to pathogens and commensals is provided. Finally, some of the future avenues that the field of fish mucosal immunity may follow in the next years are highlighted.
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DOI：
10.1016/s1570-9639(03)00018-9
发表时间：
2003-03-21
影响因子：
3.2
作者：
Birkemo, GA;Lüders, T;Nissen-Meyer, J
通讯作者：
Nissen-Meyer, J
影响因子：
2.9
作者：
Corrales, Jone;Mulero, Ivan;Noga, Edward J.
通讯作者：
Noga, Edward J.
影响因子：
2.5
作者：
Adomako, M.;St-Hilaire, S.;Sheridan, P. P.
通讯作者：
Sheridan, P. P.
影响因子：
30.3
作者：
Bates, Jennifer M.;Akerlund, Janie;Guillemin, Karen
通讯作者：
Guillemin, Karen
影响因子：
2.9
作者：
Browne, Mitchell J.;Feng, Charles Y.;Rise, Matthew L.
通讯作者：
Rise, Matthew L.