Movement-specific signaling is differentially distributed across motor cortex layer 5 projection neuron classes.
Movement-specific signaling is differentially distributed across motor cortex layer 5 projection neuron classes.
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DOI：
10.1016/j.celrep.2022.110801
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发表时间：
2022-05-10
期刊：
影响因子：
8.8
通讯作者：
Duguid, Ian
中科院分区：
文献类型：
--
作者：
Currie, Stephen P.;Ammer, Julian J.;Premchand, Brian;Dacre, Joshua;Wu, Yufei;Eleftheriou, Constantinos;Colligan, Matt;Clarke, Thomas;Mitchell, Leah;Faisal, A. Aldo;Hennig, Matthias H.;Duguid, Ian
运动皮层产生下行输出，这是执行大范围肢体运动所必需的。尽管运动相关的活动已经在整个运动皮层中被描述，但深层运动特异性信号的时空组织在很大程度上仍然未知。本研究记录了小鼠执行前肢推/拉任务时运动皮层尾侧前肢区域5B层的种群动态，发现大多数神经元表现出运动不变的反应，少数神经元表现出运动特异性。利用细胞类型特异性成像，我们发现不变反应主导锥体束（PT）神经元活动，一小部分亚群代表运动类型，而更大比例的脑内（IT）神经元显示运动类型特异性信号。IT神经元解码运动类型的比例在运动开始之前达到峰值，而PT神经元在运动执行期间达到峰值。我们的数据表明，5B层的种群动态在很大程度上反映了运动不变的信号，与运动类型相关的信息通过相对较小的、分布的投射神经元亚群传递。运动不变性反应主导着5B层的群体动态5B层投射神经元的小比例表现出运动特异性活动运动特异性在不同的投射神经元类别中分布不同IT神经元在运动开始前编码运动类型而PT神经元在运动开始后编码运动类型Currie等人表明运动类型特异性信息是通过相对较小的分布在运动皮层5B层投射神经元的亚群传递的。利用双光子群体钙成像，他们证明了运动不变的信号主导着5B层群体动态，而运动特定的信号在投射神经元类别中分布不同。
Motor cortex generates descending output necessary for executing a wide range of limb movements. Although movement-related activity has been described throughout motor cortex, the spatiotemporal organization of movement-specific signaling in deep layers remains largely unknown. Here we record layer 5B population dynamics in the caudal forelimb area of motor cortex while mice perform a forelimb push/pull task and find that most neurons show movement-invariant responses, with a minority displaying movement specificity. Using cell-type-specific imaging, we identify that invariant responses dominate pyramidal tract (PT) neuron activity, with a small subpopulation representing movement type, whereas a larger proportion of intratelencephalic (IT) neurons display movement-type-specific signaling. The proportion of IT neurons decoding movement-type peaks prior to movement initiation, whereas for PT neurons, this occurs during movement execution. Our data suggest that layer 5B population dynamics largely reflect movement-invariant signaling, with information related to movement-type being routed through relatively small, distributed subpopulations of projection neurons. Movement-invariant responses dominate layer 5B population dynamics Small proportions of layer 5B projection neurons display movement-specific activity Movement specificity is differentially distributed across projection neuron classes IT neurons encode movement type before and PT neurons after movement initiation Currie et al. show that movement-type-specific information is routed through relatively small, distributed subpopulations of motor cortical layer 5B projection neurons. Using 2-photon population calcium imaging, they demonstrate that movement-invariant signaling dominates layer 5B population dynamics, whereas movement-specific signaling is differentially distributed across projection neuron classes.
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影响因子：
2.5
作者：
CHENEY, PD;FETZ, EE;PALMER, SS
通讯作者：
PALMER, SS
小脑-丘脑皮质通路驱动行为环境相关的运动启动。
影响因子：
16.2
作者：
Dacre J;Colligan M;Clarke T;Ammer JJ;Schiemann J;Chamosa-Pino V;Claudi F;Harston JA;Eleftheriou C;Pakan JMP;Huang CC;Hantman AW;Rochefort NL;Duguid I
通讯作者：
Duguid I
影响因子：
25
作者：
Anderson, Charles T.;Sheets, Patrick L.;Kiritani, Taro;Shepherd, Gordon M. G.
通讯作者：
Shepherd, Gordon M. G.
影响因子：
5.3
作者：
Baker, Arielle;Kalmbach, Brian;Dembrow, Nikolai
通讯作者：
Dembrow, Nikolai
DOI：
10.1098/rspa.1937.0109
发表时间：
1937-05-01
影响因子：
--
作者：
Bartlett, MS
通讯作者：
Bartlett, MS