Sublayer-specific microcircuits of corticospinal and corticostriatal neurons in motor cortex.
Sublayer-specific microcircuits of corticospinal and corticostriatal neurons in motor cortex.
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DOI：
10.1038/nn.2538
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发表时间：
2010-06
影响因子：
25
通讯作者：
Shepherd, Gordon M. G.
中科院分区：
文献类型：
--
作者：
Anderson, Charles T.;Sheets, Patrick L.;Kiritani, Taro;Shepherd, Gordon M. G.
哺乳动物的运动系统是围绕着不同的皮质下子系统组织的，这表明脊髓和基底神经节上游的皮质内回路也可能是功能分化的。在这里，我们表明，小鼠运动皮层内的主要兴奋性通路，第2/3→5层，分为不同的通路，靶向皮质脊髓和皮质纹状体神经元，参与运动控制的关键细胞类别。然而，在某些子层的神经元的连接是有选择性的：皮质脊髓神经元在上层5 B，和皮质纹状体神经元在较低的5A。一个简单的结构组合原理占这种高度特定的功能电路架构：潜在的连接建立神经元子层定位，并在此框架内的实际连接是由长距离轴突投射目标。因此，这些锥体神经元的皮质内回路不仅由它们的长程轴突目标或它们的层或亚层位置指定，而且由两者以特定的组合指定。
The mammalian motor system is organized around distinct sub-cortical subsystems, suggesting that intracortical circuits immediately upstream of spinal cord and basal ganglia might be functionally differentiated, too. Here, we show that the main excitatory pathway within mouse motor cortex, layer 2/3→5, is fractionated into distinct pathways targeting corticospinal and corticostriatal neurons, key cell classes involved in motor control. However, connections were selective for neurons in certain sub-layers: corticospinal neurons in upper layer 5B, and corticostriatal neurons in lower 5A. A simple structural combinatorial principle accounts for this highly specific functional circuit architecture: potential connectivity is established by neuronal sub-layer positioning, and actual connectivity within this framework is determined by long-range axonal projection targets. Thus, intracortical circuits of these pyramidal neurons are specified not only by their long-range axonal targets, or their layer or sub-layer positions, but by both, in specific combinations.
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影响因子：
2.5
作者：
Hattox, Alexis M.;Nelson, Sacha B.
通讯作者：
Nelson, Sacha B.
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3.5
作者：
Larsen DD;Wickersham IR;Callaway EM
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Llano, D. A.;Theyel, B. B.;Issa, N. P.
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Issa, N. P.
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作者：
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通讯作者：
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