HIV-1-Mediated Acceleration of Oncovirus-Related Non-AIDS-Defining Cancers.

HIV-1-Mediated Acceleration of Oncovirus-Related Non-AIDS-Defining Cancers.
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DOI:
10.3390/biomedicines10040768
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发表时间:
2022-03-25
期刊:
影响因子:
4.7
通讯作者:
Borgmann, Kathleen
Borgmann, Kathleen
中科院分区:
工程技术3区
文献类型:
--
作者:
Proulx, Jessica;Ghaly, Maria;Park, In-Woo;Borgmann, Kathleen

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随着联合抗逆转录病毒疗法(cART)的出现,总体生存率得到了改善,获得性免疫缺陷综合症(AIDS)定义的癌症的发病率也显着降低。然而,与人类免疫缺陷病毒-1 (HIV-1) 相关的恶性肿瘤中非艾滋病定义的癌症显着增加,因此在法国等某些高度发达国家,癌症是艾滋病毒感染者的首要死因。然而,目前尚不清楚HIV-1感染如何在HIV-1和致癌病毒共同感染的患者中增加致癌病毒介导的癌症风险,因此阐明HIV-1如何在共同感染的宿主中加速致癌病毒引发的肿瘤发生的分子机制对于开发治愈或阻止癌变的治疗方法势在必行。因此,本综述的重点是 HIV-1 和致癌病毒共同感染介导的加速非艾滋病定义癌症的分子过程。
With the advent of combination antiretroviral therapy (cART), overall survival has been improved, and the incidence of acquired immunodeficiency syndrome (AIDS)-defining cancers has also been remarkably reduced. However, non-AIDS-defining cancers among human immunodeficiency virus-1 (HIV-1)-associated malignancies have increased significantly so that cancer is the leading cause of death in people living with HIV in certain highly developed countries, such as France. However, it is currently unknown how HIV-1 infection raises oncogenic virus-mediated cancer risks in the HIV-1 and oncogenic virus co-infected patients, and thus elucidation of the molecular mechanisms for how HIV-1 expedites the oncogenic viruses-triggered tumorigenesis in the co-infected hosts is imperative for developing therapeutics to cure or impede the carcinogenesis. Hence, this review is focused on HIV-1 and oncogenic virus co-infection-mediated molecular processes in the acceleration of non-AIDS-defining cancers.
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