Bone Substitute Fabrication Based on Dissolution-Precipitation Reactions

Bone Substitute Fabrication Based on Dissolution-Precipitation Reactions
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DOI:
10.3390/ma3021138
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发表时间:
2010-02-10
期刊:
影响因子:
3.4
通讯作者:
Ishikawa K
Ishikawa K
中科院分区:
材料科学3区
文献类型:
--
作者:
Ishikawa K

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尽管块状或颗粒状烧结羟基磷灰石具有优异的组织反应和良好的骨导电性,但磷灰石粉末会引起炎症反应。对于羟基磷灰石块或颗粒的制备,通常采用烧结方法。然而,骨骼和牙齿的无机成分不是高晶羟基磷灰石,而是低晶b型碳酸盐磷灰石。碳酸盐磷灰石粉体在高温下不稳定,不能烧结。制备磷灰石块和/或颗粒的另一种方法是利用前驱相通过基于溶解-沉淀反应的相变。这个反应基本上与硫酸钙或石膏的凝固和硬化反应相同。本文讨论了基于溶解-沉淀反应的相变制备磷灰石块的方法,重点讨论了硫酸钙凝固和硬化反应的相似性。
Although block- or granular-type sintered hydroxyapatite are known to show excellent tissue responses and good osteoconductivity, apatite powder elicits inflammatory response. For the fabrication of hydroxyapatite block or granules, sintering is commonly employed. However, the inorganic component of bone and tooth is not high crystalline hydroxyapatite but low crystalline B-type carbonate apatite. Unfortunately, carbonate apatite powder cannot be sintered due to its instability at high temperature. Another method to fabricate apatite block and/or granule is through phase transformation based on dissolution-precipitation reactions using a precursor phase. This reaction basically is the same as a setting and hardening reaction of calcium sulfate or plaster. In this paper, apatite block fabrication methods by phase transformation based on dissolution-precipitation reactions will be discussed, with a focus on the similarity of the setting and hardening reaction of calcium sulfate.
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