Hyaluronan in the pathogenesis of acute and post-acute COVID-19 infection.
Hyaluronan in the pathogenesis of acute and post-acute COVID-19 infection.
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透明质酸在急性和急性后共证感染的发病机理中。
DOI：
10.1016/j.matbio.2023.02.001
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发表时间：
2023-03
期刊：
影响因子：
6.9
通讯作者：
Bollyky, Paul L.
中科院分区：
文献类型：
--
作者：
Barnes, Henry W.;Demirdjian, Sally;Haddock, Naomi L.;Kaber, Gernot;Martinez, Hunter A.;Nagy, Nadine;Karmouty-Quintana, Harry;Bollyky, Paul L.
严重急性呼吸综合征冠状病毒2(SARS-CoV-2)最近成为一场全球大流行的原因。感染SARS-CoV-2可导致新冠肺炎同时出现急性和慢性疾病表现，在病毒复制消除后很长一段时间内仍会继续影响许多患者。因此，人们对了解导致新冠肺炎发病的宿主因素非常感兴趣。在这篇综述中，我们讨论了透明质酸(HA)，一种在炎症和细胞代谢中发挥作用的细胞外基质聚合物在新冠肺炎中的作用，并对HA促进新冠肺炎发病的假说进行了批判性评估。我们首先对新冠肺炎感染做一个简单的概述。然后简要总结了HA在呼吸道炎症和免疫中的已知作用。然后，我们将阐述已知的HA和新冠肺炎急性呼吸窘迫综合征(新冠肺炎ARDS)的发病机制。接下来，我们研究了HA在急性SARS-CoV-2感染(PASC)(也称为“长冠状病毒病”)以及冠状病毒相关性纤维化中的潜在作用。最后，我们讨论了以HA为靶点治疗新冠肺炎的潜在疗法，包括改变用途的药物Hymecroone(4-甲基伞形酮)。我们认为，HA是治疗新冠肺炎的一个有前景的潜在治疗靶点。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently emerged as the cause of a global pandemic. Infection with SARS-CoV-2 can result in COVID-19 with both acute and chronic disease manifestations that continue to impact many patients long after the resolution of viral replication. There is therefore great interest in understanding the host factors that contribute to COVID-19 pathogenesis. In this review, we address the role of hyaluronan (HA), an extracellular matrix polymer with roles in inflammation and cellular metabolism, in COVID-19 and critically evaluate the hypothesis that HA promotes COVID-19 pathogenesis. We first provide a brief overview of COVID-19 infection. Then we briefly summarize the known roles of HA in airway inflammation and immunity. We then address what is known about HA and the pathogenesis of COVID-19 acute respiratory distress syndrome (COVID-19 ARDS). Next, we examine potential roles for HA in post-acute SARS-CoV-2 infection (PASC), also known as “long COVID” as well as in COVID-associated fibrosis. Finally, we discuss the potential therapeutics that target HA as a means to treat COVID-19, including the repurposed drug hymecromone (4-methylumbelliferone). We conclude that HA is a promising potential therapeutic target for the treatment of COVID-19.
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