Post-COVID-19 Pulmonary Fibrosis: Novel Sequelae of the Current Pandemic.
Post-COVID-19 Pulmonary Fibrosis: Novel Sequelae of the Current Pandemic.
复制标题
DOI：
10.3390/jcm10112452
复制
发表时间：
2021-06-01
影响因子：
3.9
通讯作者：
Collen JF
中科院分区：
文献类型：
--
作者：
Ambardar SR;Hightower SL;Huprikar NA;Chung KK;Singhal A;Collen JF
自2019年12月首次发现新型冠状病毒SARS-CoV-2以来，新冠肺炎大流行已成为全球发病率和死亡率的主要原因。随着有效的疫苗和治疗方法开始出现，识别和主动管理严重疾病的长期呼吸道并发症将变得越来越重要。影像异常的模式结合以往冠状病毒暴发的数据表明，严重新冠肺炎肺炎患者发展为间质性肺疾病和慢性肺血管疾病的风险可能增加。本文就间质性肺病(ILD)的定义、分类和基本病理生理学作一综述。然后，我们回顾了目前关于新冠肺炎严重感染时肺损伤机制的文献，并概述了与新冠肺炎后肺纤维化发展有关的潜在的病毒和免疫介导的过程。最后，我们讨论了可能导致PCPF的特定患者和医源性危险因素，并讨论了降低肺部并发症/后遗症风险的策略。
Since the initial identification of the novel coronavirus SARS-CoV-2 in December 2019, the COVID-19 pandemic has become a leading cause of morbidity and mortality worldwide. As effective vaccines and treatments begin to emerge, it will become increasingly important to identify and proactively manage the long-term respiratory complications of severe disease. The patterns of imaging abnormalities coupled with data from prior coronavirus outbreaks suggest that patients with severe COVID-19 pneumonia are likely at an increased risk of progression to interstitial lung disease (ILD) and chronic pulmonary vascular disease. In this paper, we briefly review the definition, classification, and underlying pathophysiology of interstitial lung disease (ILD). We then review the current literature on the proposed mechanisms of lung injury in severe COVID-19 infection, and outline potential viral- and immune-mediated processes implicated in the development of post-COVID-19 pulmonary fibrosis (PCPF). Finally, we address patient-specific and iatrogenic risk factors that could lead to PCPF and discuss strategies for reducing risk of pulmonary complications/sequelae.
登录
查看更多内容
影响因子：
8.8
作者：
Burnham EL;Hyzy RC;Paine R 3rd;Coley C 2nd;Kelly AM;Quint LE;Lynch D;Janssen WJ;Moss M;Standiford TJ
通讯作者：
Standiford TJ
感染在间质性肺部疾病中的作用：综述。
影响因子：
9.6
作者：
Azadeh N;Limper AH;Carmona EM;Ryu JH
通讯作者：
Ryu JH
DOI：
10.1183/09031936.00196412
发表时间：
2014-01
期刊：
The European respiratory journal
影响因子：
--
作者：
Burnham EL;Janssen WJ;Riches DW;Moss M;Downey GP
通讯作者：
Downey GP
DOI：
10.1164/rccm.201605-1081cp
发表时间：
2017-02-15
影响因子：
24.7
作者：
Brochard, Laurent;Slutsky, Arthur;Pesenti, Antonio
通讯作者：
Pesenti, Antonio
DOI：
10.4103/ijri.ijri_469_16
发表时间：
2017-07
期刊：
The Indian journal of radiology & imaging
影响因子：
--
作者：
Das KM;Lee EY;Singh R;Enani MA;Al Dossari K;Van Gorkom K;Larsson SG;Langer RD
通讯作者：
Langer RD