Metalworking fluid exposure and cancer risk in a retrospective cohort of female autoworkers.
Metalworking fluid exposure and cancer risk in a retrospective cohort of female autoworkers.
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女性汽车工人回顾性队列中的金属加工液暴露和癌症风险。
DOI：
10.1007/s10552-012-9976-z
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Eisen,EllenA
中科院分区：
文献类型：
--
作者：
Friesen,MelissaC;Betenia,Nicole;Costello,Sadie;Eisen,EllenA
金属加工液（MWFs）已被证实与多个部位的癌症有关，但其风险主要是在男性或在分析中调整性别的研究中进行的。为了评估女性的风险是否相似，我们报告了联合汽车工人-通用汽车汽车工人队列中的4,825名女性汽车工人的癌症死亡风险。方法根据密歇根州1980-2004年死亡率计算标准化死亡率（SMRs）。内部比较（1941-2004）使用Cox回归对直接、可溶性和合成MWFs及其相应的油基和水基馏分进行了检验。结果女性人群中smwf暴露水平普遍低于男性人群中MWF暴露水平的三分之二。女性汽车工人在所有地点的癌症（SMR, 1.10； 95%可信区间（CI）， 0.98-1.22）和肺癌（SMR, 2.08; 95% CI, 1.71-2.52）都有过量。直接（矿物油）MWF暴露增加结肠癌风险（暴露bb0中位数；风险比= 3.1;95% CI, 1.2-8.0）。观察到可溶性MWF和水基MWF指标对卵巢癌的保护作用。尽管膀胱癌、直肠癌、喉癌和恶性黑色素瘤与男性直接接触MWF和胰腺癌合并合成MWF有关，但该女性亚队列中死亡人数太少，无法检查这些部位的暴露-反应关系。肺癌和乳腺癌的研究结果为零。结论：我们的研究结果支持结肠癌与直MWFs之间的联系，但我们发现女性汽车工人在较低暴露水平下对其他肿瘤部位的风险的证据有限。
ObjectivesMetalworking fluids (MWFs) have been associated with cancer of several sites, but the risks have been primarily examined in men or in studies that adjusted for gender in analyses. To evaluate whether risks were similar in women, we report cancer mortality risk among 4,825 female autoworkers within the united autoworkers–general motors autoworkers cohort.MethodsStandardized mortality rates (SMRs) were calculated based on Michigan death rates (1980–2004). Internal comparisons (1941–2004) were examined using Cox regression for straight, soluble, and synthetic MWFs, and their corresponding oil- and water-based fractions.ResultsMWF exposure levels in the female cohort were generally less than two-third the MWF levels in the male cohort. Female autoworkers had an excess of cancer from all sites (SMR, 1.10; 95 % confidence interval (CI), 0.98–1.22) and lung cancer (SMR, 2.08; 95 % CI, 1.71–2.52). Colon cancer risk increased with straight (mineral oil) MWF exposure (exposure > median; hazard ratio = 3.1; 95 % CI, 1.2–8.0). A protective effect was observed for ovarian cancer with the soluble MWFs and water-based MWF metrics. Although bladder, rectal, and laryngeal cancers and malignant melanoma have been associated with straight MWF exposure and pancreatic cancer with synthetic MWF in men, there were too few deaths in this female subcohort to examine exposure–response relations for these sites. Results were null for lung and breast cancer.ConclusionsOur findings support an association between colon cancer and straight MWFs, but we found limited evidence of risk for other tumor sites at the lower exposure levels experienced by the female autoworkers.
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