Maximal oxygen consumption in relation to subordinate traits in lines of house mice selectively bred for high voluntary wheel running.
Maximal oxygen consumption in relation to subordinate traits in lines of house mice selectively bred for high voluntary wheel running.
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选择性饲养的高自愿轮跑家鼠品系的最大耗氧量与从属特征的关系。
DOI：
10.1152/japplphysiol.00042.2006
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发表时间：
2006
影响因子：
3.3
通讯作者：
T. Garland
中科院分区：
文献类型：
--
作者：
E. Rezende;F. Gomes;Jessica L. Malisch;M. Chappell;T. Garland
我们研究了最大耗氧量（VO2最大值）之间的关系，在强迫运动和从属性状与血液O2运输和细胞呼吸在四个线的小鼠选择性繁殖高自愿轮运行（S线）和他们的四个非选择的控制（C）线。以前，我们报告了59名女性在三个氧分压（缺氧= 14%O2，常氧= 21%，高氧= 30%）的最大摄氧量。在这里，我们测试的假设，VO2最大值的变化可以解释，部分，血红蛋白浓度和PO2需要获得50%的氧饱和度的血红蛋白（血红蛋白对O2的亲和力估计）的血液以及柠檬酸合酶的活性和肌红蛋白浓度的心室和腓肠肌。统计分析控制体重，比较S和C系，并考虑了小肌肉表型（仅存在于S系中，由孟德尔隐性等位基因引起）的影响，这减少了后肢肌肉质量，同时增加了肌肉质量特异性有氧能力。虽然S系有较高的VO2最大值比C，从属性状没有表现出统计学差异时，存在的迷你肌肉表型控制。然而，从属性状没有解释一些VO2最大值的个体差异。在所有三个Po2下，动脉瘤大小是VO2 max的正预测因子。血液Hb浓度是一个积极的预测VO2最大值在S线，但在C线的负预测，表明VO2最大值的生理基础已被改变的选择性育种。具有小肌肉表型的小鼠具有扩大的心室，具有更高的质量特异性柠檬酸合酶活性和肌红蛋白浓度，这可能是其在缺氧时更高的VO2 max的原因。
We studied relations between maximal O2 consumption (VO2 max) during forced exercise and subordinate traits associated with blood O2 transport and cellular respiration in four lines of mice selectively bred for high voluntary wheel running (S lines) and their four nonselected control (C) lines. Previously, we reported VO2 max of 59 females at three Po2 (hypoxia = 14% O2, normoxia = 21%, hyperoxia = 30%). Here, we test the hypothesis that variation in VO2 max can be explained, in part, by hemoglobin concentration and Po2 necessary to obtain 50% O2 saturation of Hb (an estimate of Hb affinity for O2) of the blood as well as citrate synthase activity and myoglobin concentration of ventricles and gastrocnemius muscle. Statistical analyses controlled for body mass, compared S and C lines, and also considered effects of the mini-muscle phenotype (present only in S lines and resulting from a Mendelian recessive allele), which reduces hindlimb muscle mass while increasing muscle mass-specific aerobic capacity. Although S lines had higher VO2 max than C, subordinate traits showed no statistical differences when the presence of the mini-muscle phenotype was controlled. However, subordinate traits did account for some of the individual variation in VO2 max. Ventricle size was a positive predictor of VO2 max at all three Po2. Blood Hb concentration was a positive predictor of VO2 max in S lines but a negative predictor in C lines, indicating that the physiological underpinnings of VO2 max have been altered by selective breeding. Mice with the mini-muscle phenotype had enlarged ventricles, with higher mass-specific citrate synthase activity and myoglobin concentration, which may account for their higher VO2 max in hypoxia.
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DOI：
10.1152/ajpregu.2001.280.2.r441
发表时间：
2001-02-01
影响因子：
2.8
作者：
Leek, BT;Mudaliar, SRD;Richardson, RS
通讯作者：
Richardson, RS
骨骼肌：心血管系统的主人还是奴隶？
影响因子：
4.1
作者：
Richardson,RS;Harms,CA;Grassi,B;Hepple,RT
通讯作者：
Hepple,RT
影响因子：
4.6
作者：
Koch, LG;Britton, SL
通讯作者：
Britton, SL
人类有氧运动表现：关于 V(O(2)) 限制的争论太多了。
DOI：
10.1242/jeb.204.18.3195
发表时间：
2001
期刊：
The Journal of experimental biology
影响因子：
--
作者：
Lindstedt,SL;Conley,KE
通讯作者：
Conley,KE
自愿活动和遗传选择对家鼠（Mus homeus）有氧能力的影响。
DOI：
10.1152/jappl.1998.84.1.69
发表时间：
1998
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Swallow,JG;GarlandJr,T;Carter,PA;Zhan,WZ;Sieck,GC
通讯作者：
Sieck,GC