Polymer Microneedle Mediated Local Aptamer Delivery for Blocking the Function of Vascular Endothelial Growth Factor.
Polymer Microneedle Mediated Local Aptamer Delivery for Blocking the Function of Vascular Endothelial Growth Factor.
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DOI：
10.1021/acsbiomaterials.7b00718
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发表时间：
2017-12-11
影响因子：
5.8
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Coyne J;Davis B;Kauffman D;Zhao N;Wang Y
Overexpression of proteins in the body can cause severe diseases and other physiological disturbances. The development of protein blockers and local delivery systems would offer opportunities for addressing the health problems caused by protein overexpression. Nucleic acid aptamers are an emerging class of ligands with the potential to block proteins effectively; however, little effort has been made in developing polymer systems for local aptamer delivery. In this work, polymer microneedles capable of delivering DNA aptamers locally to inhibit the function of vascular endothelial growth factor (VEGF) were developed and studied. The presence of anti-VEGF aptamer in the polymer matrix did not change the apparent mechanical strength of the microneedles. Once in contact with a physiological solution, the polymer microneedles quickly dissolved, generating a high concentration of anti-VEGF aptamer in the surrounding local microenvironment. Aptamer delivery by way of dissolving polymer microneedles in a tissue phantom reduced VEGF-mediated endothelial cell tube formation. Thus, aptamer-loaded polymer microneedles hold great potential as a therapeutic tool for the treatment of human diseases resulting from protein overexpression.
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影响因子：
46.9
作者：
Dassie, Justin P.;Liu, Xiu-ying;Thomas, Gregory S.;Whitaker, Ryan M.;Thiel, Kristina W.;Stockdale, Katie R.;Meyerholz, David K.;McCaffrey, Anton P.;McNamara, James O., II;Giangrande, Paloma H.
通讯作者：
Giangrande, Paloma H.
影响因子：
2.3
作者：
Gittard SD;Chen B;Xu H;Ovsianikov A;Chichkov BN;Monteiro-Riviere NA;Narayan RJ
通讯作者：
Narayan RJ
用聚乳酸-乙醇酸微球控制抗 VEGF 适体 EYE001 的递送
影响因子：
4.4
作者：
Carrasquillo, KG;Ricker, JA;Adamis, AP
通讯作者：
Adamis, AP
影响因子：
4.4
作者：
Jiang, Jason;Gill, Harvinder S.;Prausnitz, Mark R.
通讯作者：
Prausnitz, Mark R.
影响因子：
19
作者：
Chaouat, Marc;Le Visage, Catherine;Letourneur, Didier
通讯作者：
Letourneur, Didier