The Effects of Geometry on Skin Penetration and Failure of Polymer Microneedles.
The Effects of Geometry on Skin Penetration and Failure of Polymer Microneedles.
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DOI：
10.1080/01694243.2012.705101
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发表时间：
2013-02-01
影响因子：
2.3
通讯作者：
Narayan RJ
中科院分区：
文献类型：
--
作者：
Gittard SD;Chen B;Xu H;Ovsianikov A;Chichkov BN;Monteiro-Riviere NA;Narayan RJ
微针是可用于药物递送和生物传感的小规模装置。在本研究中，检查了机械失效所需的力、机械失效模式以及微针穿透猪皮肤的机制。使用涉及双光子聚合和聚（二甲基硅氧烷）微成型的间接快速原型方法，从丙烯酸酯基聚合物e-Shell 200生产的针头被发现具有足够的强度穿透猪皮。失效力比完全插入皮肤所需的力大一个数量级。弯曲是最常见的失效形式;增加纵横比和减小头端直径与较低的失效力相关。在皮肤穿透过程中捕获的视频显示，微针穿透皮肤是通过一系列插入而不是通过单次插入事件发生的。在皮肤渗透期间和之后获得的图像证实了皮肤的微针渗透以及荧光黄染料的透皮递送。这些发现揭示了微针穿透和失效的机制，促进了聚合物微针的设计改进。
Microneedles are small-scale devices that may be used for drug delivery and biosensing. In this study, the forces required for mechanical failure, the modes of mechanical failure, as well as the mechanisms for microneedle penetration into porcine skin were examined. Microneedles produced from the acrylate-based polymer e-Shell 200 using an indirect rapid prototyping approach involving two-photon polymerization and poly(dimethylsiloxane) micromolding were found to possess sufficient strength for penetration of porcine skin. The failure forces were an order of magnitude greater than the forces necessary for full insertion into the skin. Bending was the most common form of failure; an increasing aspect ratio and a decreasing tip diameter were associated with lower failure forces. Video captured during skin penetration revealed that microneedle penetration into the skin occurred by means of a series of insertions and not by means of a single insertion event. Images obtained during and after skin penetration confirmed microneedle penetration of skin as well as transdermal delivery of lucifer yellow dye. These findings shed insight into the mechanisms of microneedle penetration and failure, facilitating design improvements for polymer microneedles.
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