Time-dependent, dynamic prediction of fatty acid-binding protein 4, Galectin-3, and soluble ST2 measurement with poor outcome after acute stroke.
Time-dependent, dynamic prediction of fatty acid-binding protein 4, Galectin-3, and soluble ST2 measurement with poor outcome after acute stroke.
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DOI：
10.1177/1747493020971166
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Kimberly WT
中科院分区：
文献类型：
--
作者：
Hansen C;Sastre C;Wolcott Z;Bevers MB;Kimberly WT
卒中后生物标志物水平的时间依赖性变化尚不清楚。我们试图比较脂肪酸结合蛋白4（FABP 4）、半乳糖凝集素-3（Gal-3）和可溶性ST 2（sST 2），以确定入院时和48小时后预测结果的变化。在急性中风患者入院时（n=383）和48小时后（n=244）的生物标本中测量血浆FABP 4、Gal-3和sST 2。在90天时使用改良兰金量表（mRS）评估功能结局，分为良好（mRS 0-2）和不良结局（mRS 3-6）。入院时，每种生物标志物水平升高预示预后不良（FABP 4：OR 1.92，95%CI 1.42-2.59，P<0.0001; Gal-3：OR 1.85，95%CI 1.42-2.40，P<0.0001; sST 2：OR 1.55，95%CI 1.22-1.97，P<0.0001）和死亡（FABP4：OR 2.45; 95%CI 1.51-3.98; P<0.0001; Gal-3：OR 2.12; 95%CI 1.50-3.30; P<0.0001; sST 2：OR 2.17; 95%CI 1.58-2.99; P<0.0001）。在48小时，sST 2预测不良结局（OR 2.62，95%CI 1.77-3.88，P<0.0001）和死亡率（OR 3.36，95%CI 2.06-5.48，P<0.0001），Gal-3仅预测死亡率（OR 1.81，95%CI 1.05-3.10，P=0.033）。在48小时测量的FABP 4不能预测结局或死亡。Gal-3和sST 2与预后或死亡率的相关性与年龄、性别和NIHSS无关，而与FABP 4相关的患者则无关。Gal-3在入院时测量时表现更好，而可溶性ST 2在入院时具有预测性，在卒中后48小时更好。时间依赖性差异可能反映了急性卒中后这些通路的演变作用。
Time-dependent change in the level of biomarkers after stroke is not well understood. We sought to compare Fatty Acid Binding Protein 4 (FABP4), Galectin-3 (Gal-3), and soluble ST2 (sST2), to ascertain for a change in prediction of outcome at admission and 48 hours later. Plasma FABP4, Gal-3, and sST2 were measured in biospecimens from acute stroke patients at the time of admission (n=383) and 48 hours later (n=244). Functional outcome was assessed at 90 days using the modified Rankin Scale (mRS), dichotomized into good (mRS 0-2) and poor outcome (mRS 3-6). On admission, elevated levels of each biomarker predicted poor outcome (FABP4: OR 1.92, 95% CI 1.42-2.59, P<0.0001; Gal-3: OR 1.85, 95% CI 1.42-2.40, P<0.0001; sST2: OR 1.55, 95% CI 1.22-1.97, P<0.0001) and death (FABP4: OR 2.45; 95% CI 1.51-3.98; P<0.0001; Gal-3: OR 2.12; 95% CI 1.50-3.30; P<0.0001; sST2: OR 2.17; 95% CI 1.58-2.99; P<0.0001). At 48 hours, sST2 predicted poor outcome (OR 2.62, 95% CI 1.77-3.88, P<0.0001) and mortality (OR 3.36, 95% CI 2.06-5.48, P<0.0001), and Gal-3 predicted mortality only (OR 1.81, 95% CI 1.05-3.10, P=0.033). FABP4 measured at 48 hours was not predictive of outcome or death. Associations of Gal-3 and sST2 with outcome or mortality were independent of age, sex, and NIHSS, whereas those with FABP4 were not. Gal-3 performed better when measured on admission, whereas soluble ST2 was predictive at admission and better at 48 hours after stroke. The time-dependent differences may reflect the evolving role of these pathways after acute stroke.
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影响因子：
5.3
作者：
Yang, Yuanyuan;Liu, Huan;Hu, Xiaoming
通讯作者：
Hu, Xiaoming
影响因子：
37.8
作者：
Sabatine, Marc S.;Morrow, David A.;Lee, Richard T.
通讯作者：
Lee, Richard T.
急性缺血性中风患者的血清半乳糖凝集素 3 与不良预后
影响因子：
8.3
作者：
Wang, Aili;Zhong, Chongke;He, Jiang
通讯作者：
He, Jiang
星形胶质细胞衍生的白介素-33促进了小胶质的突触吞噬和神经回路的发育。
DOI：
10.1126/science.aal3589
发表时间：
2018-03-16
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Vainchtein ID;Chin G;Cho FS;Kelley KW;Miller JG;Chien EC;Liddelow SA;Nguyen PT;Nakao-Inoue H;Dorman LC;Akil O;Joshita S;Barres BA;Paz JT;Molofsky AB;Molofsky AV
通讯作者：
Molofsky AV
循环 FABP4（脂肪酸结合蛋白 4）是急性缺血性中风患者的一种新型预后生物标志物
影响因子：
8.3
作者：
Tu, Wen-Jun;Zeng, Xian-Wei;Liu, Qiang
通讯作者：
Liu, Qiang